MAGEA1
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Official Full Name
melanoma antigen family A, 1 (directs expression of antigen MZ2-E) -
Overview
Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues. -
Synonyms
MAGEA1;melanoma antigen family A, 1 (directs expression of antigen MZ2-E);MAGE1;melanoma-associated antigen 1;cancer/testis antigen family 1;member 1;CT1.1;melanoma antigen family A 1;melanoma antigen MAGE 1;melanoma associated antigen 1;melanoma associated antigen MZ2 E;MGC9326;antigen MZ2-E;MAGE-1 antigen;melanoma antigen MAGE-1;cancer/testis antigen 1.1;melanoma-associated antigen MZ2-E;cancer/testis antigen family 1, member 1
Recombinant Proteins
- Human
- E.coli
- HEK293
- Yeast
- Mammalian Cells
- Non
- His&Fc&Avi
- His
- His&T7
- FLAG
- Myc&DDK
- GST
- Flag&Myc
- Fc
- Flag
Involved Pathway
MAGEA1 involved in several pathways and played different roles in them. We selected most pathways MAGEA1 participated on our site, such as Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAGEA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Delta-Notch Signaling Pathway | TUBB3,ADAM10A,SAP30,HES6,TCF3B,HEY2,ASCL1A,TLE1,JAG2,YY1A |
Protein Function
MAGEA1 has several biochemical functions, for example, histone deacetylase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAGEA1 itself. We selected most functions MAGEA1 had, and list some proteins which have the same functions with MAGEA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone deacetylase binding | RAD9A,BCOR,XBP1,TOP2A,NACC2,PKN1,NIPBL,SKOR2,USF1,HEY2 |
| protein binding | C9orf78,PRKRIP1,KLHL12,GABPB1,TCF3,PDE1B,TCEANC,DKK1,PDCL,FABP5 |
Interacting Protein
MAGEA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAGEA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAGEA1.
TRIM31;MIEF1;SELPLG;SFN;TRIM31;PBX3
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