MAFF
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Official Full Name
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -
Overview
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009] -
Synonyms
MAFF;v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F;U-MAF;hMafF;transcription factor MafF;v-maf avian musculoaponeurotic fibrosarcoma oncogene family protein F
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
MAFF involved in several pathways and played different roles in them. We selected most pathways MAFF participated on our site, such as Factors involved in megakaryocyte development and platelet production,Hemostasis,Myometrial Relaxation and Contraction Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAFF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Myometrial Relaxation and Contraction Pathways | ADM,RGS6,IGFBP2,GUCA2B,GUCA2A,CORIN,CRCP,RAMP3,RGS17,GPR182 |
| Hemostasis | CFHL3,CD84,MAFGA,CXADR,PDPN,MERTK,ABHD12,HBG2,S100A10,GNA13 |
| Factors involved in megakaryocyte development and platelet production | SH2B3,IRF1B,DOCK6,KIF5A,VPS45,HBD,HBG1,BA1,CBX5,CABLES2 |
Protein Function
MAFF has several biochemical functions, for example, sequence-specific DNA binding,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAFF itself. We selected most functions MAFF had, and list some proteins which have the same functions with MAFF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | TP63,NR5A5,FOXN2,THRB,ERF,CREB5,FOXC1B,FOXE3,SALL1,ZKSCAN14 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | TBX5,PKNOX1,GATA1,GATA5,GATA2B,NKX2,GLIS1,CREBBP,GRHL3,ELF5 |
Interacting Protein
MAFF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAFF here. Most of them are supplied by our site. Hope this information will be useful for your research of MAFF.
Bach1;OVOL1;PSAP;MAFIP;BACH1
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References
- Newton, JR; Wood, JLN; et al. Serological surveillance of equine viral arteritis in the United Kingdom since the outbreak in 1993. VETERINARY RECORD 145:511-516(1999).
- IGARASHI, K; ITOH, K; et al. ACTIVITY AND EXPRESSION OF MURINE SMALL MAF FAMILY PROTEIN MAFK. JOURNAL OF BIOLOGICAL CHEMISTRY 270:7615-7624(1995).
