MAFB
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Official Full Name
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B -
Overview
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns. [provided by RefSeq, Jul 2008] -
Synonyms
MAFB;v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B;KRML;MCTO;transcription factor MafB;Kreisler maf-related leucine zipper homolog;MAFB/Kreisler basic region/leucine zipper transcription factor
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His&T7
- His
- Non
- Avi&Fc&His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MAFB-218H | Recombinant Human MAFB protein, T7/His-tagged | E.coli | Human | His&T7 |
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| MAFB-2547C | Recombinant Chicken MAFB | Mammalian Cells | Chicken | His |
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| MAFB-3534R | Recombinant Rat MAFB Protein | Mammalian Cells | Rat | His |
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| MAFB-9438M | Recombinant Mouse MAFB Protein | Mammalian Cells | Mouse | His |
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| MAFB-4561HCL | Recombinant Human MAFB 293 Cell Lysate | HEK293 | Human | Non |
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| MAFB-01H | Recombinant Human MAFB protein, His-tagged | E.coli | Human | His |
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| MAFB-3190R | Recombinant Rat MAFB Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| MAFB-3190R-B | Recombinant Rat MAFB Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| MAFB-5297M | Recombinant Mouse MAFB Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| MAFB-5297M-B | Recombinant Mouse MAFB Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MAFB involved in several pathways and played different roles in them. We selected most pathways MAFB participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MAFB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MAFB has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein binding,transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAFB itself. We selected most functions MAFB had, and list some proteins which have the same functions with MAFB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | GRHL3,GABPA,PLAGL1,HOXD8,CTCF,GATA1A,SRF,IRF2,MSX1,GATA2B |
| protein binding | COMMD1,SLC35F6,RBFA,F12,CHPF,FAM168A,IL2RB,MAPK4,TPT1,STXBP2 |
| transcription factor binding | MDFIC,PDX1,E2F5,HMGB1,PSMD10,PSMD4,UBA2,GATA4,DRAP1,POU1F1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | MYOG,PITX2,NR1H4,GATA3,ZSCAN21,CRX,ELK3,NUCKS1,TFAP2E,MITF |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | AGO1,ZFP746,MYPOP,MITF,NEUROD1,JUNBA,HELT,HIST2H3A,ATOH1,IRF1 |
Interacting Protein
MAFB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAFB here. Most of them are supplied by our site. Hope this information will be useful for your research of MAFB.
HBZ;IRF3;BACH1;MAF;FOS;FOSL2;ATF3;NFE2L1;IKBKE;IRF7;ZWINT;prdm1_human_gene
Resources
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References
- Aida, Y; Shibata, Y; et al. Inhibition of Elastase-Pulmonary Emphysema in Dominant-Negative MafB Transgenic Mice. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 10:882-894(2014).
- Herath, NI; Rocques, N; et al. GSK3-mediated MAF phosphorylation in multiple myeloma as a potential therapeutic target. BLOOD CANCER JOURNAL 4:-(2014).
