MAF

  • Official Full Name

    v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

  • Overview

    The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    MAF;v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian);v maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog;transcription factor Maf;c MAF;AS42 oncogene homolog;Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene;Avian musculoaponeurotic fibrosarcoma (v maf);c maf proto oncogene;cMaf;MAF_HUMAN;MAF2;MGC71685;Proto oncogene c Maf;Proto-oncogene c-maf;v maf musculoaponeurotic fibrosarcoma oncogene homolog (avian);v maf musculoaponeurotic fibrosarcoma oncogene homolog;V-maf musculoaponeurotic fibrosarcoma oncogene homolog;OTTHUMP00000174965;OTTHUMP00000196745;c-maf proto-oncogene;T lymphocyte c-maf long form;c-MAF

Recombinant Proteins

  • Bacillus subtilis
  • Human
  • Chicken
  • Rat
  • Zebrafish
  • Mouse
  • E.Coli/Yeast
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • Avi&Fc&His
Cat.# Product name Source (Host) Species Tag Protein Length Price
MAF-0344B Recombinant Bacillus subtilis MAF protein, His-tagged E.Coli/Yeast Bacillus subtilis His
MAF-26878TH Recombinant Human MAF Wheat Germ Human Non 100 amino acids
MAF-3463C Recombinant Chicken MAF Mammalian Cells Chicken His
MAF-3532R Recombinant Rat MAF Protein Mammalian Cells Rat His
MAF-9351Z Recombinant Zebrafish MAF Mammalian Cells Zebrafish His
MAF-9435M Recombinant Mouse MAF Protein Mammalian Cells Mouse His
MAF-3188R Recombinant Rat MAF Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
MAF-3188R-B Recombinant Rat MAF Protein Pre-coupled Magnetic Beads HEK293 Rat
MAF-5294M Recombinant Mouse MAF Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
MAF-5294M-B Recombinant Mouse MAF Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    MAF involved in several pathways and played different roles in them. We selected most pathways MAF participated on our site, such as Transcriptional misregulation in cancer,Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with MAF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Inflammatory bowel disease (IBD) HLA-DRB5,IL17F,TGFB2,GATA3,IL12B,FOXP3,IL2RG,SMAD3,TLR4,IL6
    Transcriptional misregulation in cancer IL1R2,SLC45A3,NFKBIZ,HOXA9,MMP9,NR4A3,PAX3,PML,JMJD1C,RUNX2

    Protein Function

    MAF has several biochemical functions, for example, protein binding,sequence-specific DNA binding,transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAF itself. We selected most functions MAF had, and list some proteins which have the same functions with MAF. You can find most of the proteins on our site.

    Function Related Protein
    protein binding KRTAP10-4,EDDM3B,IRF7,GNB2L1,METTL17,HIST2H3C,ATXN7L3,HIST1H2AI,CCPG1,NKAP
    sequence-specific DNA binding FOXO3A,ZBTB33,PPARGC1A,HOXB13A,LHX9,HOXA11A,NOTCH1,NR5A5,LMX1BB,ELK4
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding SRF,ATF1,STAG2,REST,RFX6,IKZF3,GATA6,MYOG,BARX1,DLX2

    Interacting Protein

    MAF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAF here. Most of them are supplied by our site. Hope this information will be useful for your research of MAF.

    BACH1;HBZ;ATF4;MAFB;AHR;nusA

    Resources

    Research Area

    Apoptosis Transcription Factors and Regulators
    Cancer Stem Cell Transcription Factors
    Epithelial Stem Cell Transcription Factors
    Hematopoietic Stem Cell Transcription Factors and Regulators
    Embryonic and Induced Pluripotent Stem Cell Markers
    Pluripotent Stem Cell Transcription Factors
    Natural Killer T (NKT) Cells
    Prostate Cancer Stem Cell Markers
    Glioma/Medulloblastoma Cancer Stem Cell Markers

    References

    • Xie, J; Cui, DW; et al. Changes in Follicular Helper T Cells in Idiopathic Thrombocytopenic Purpura Patients. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 11:220-229(2015).
    • Ma, CS; Uzel, G; et al. Human T follicular helper cells in primary immunodeficiencies. CURRENT OPINION IN PEDIATRICS 26:720-726(2014).

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