MAEL
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Official Full Name
maelstrom homolog (Drosophila) -
Overview
Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage. -
Synonyms
MAEL;maelstrom homolog (Drosophila);AU019877;4933405K18Rik;protein maelstrom homolog
Recombinant Proteins
- Rhesus macaque
- Mouse
- Human
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MAEL-2622R | Recombinant Rhesus monkey MAEL Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| MAEL-9434M | Recombinant Mouse MAEL Protein | Mammalian Cells | Mouse | His |
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| MAEL-4564HCL | Recombinant Human MAEL 293 Cell Lysate | HEK293 | Human | Non |
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| MAEL-2442R | Recombinant Rhesus Macaque MAEL Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| MAEL-2442R-B | Recombinant Rhesus Macaque MAEL Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| MAEL-5293M | Recombinant Mouse MAEL Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| MAEL-5293M-B | Recombinant Mouse MAEL Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
MAEL involved in several pathways and played different roles in them. We selected most pathways MAEL participated on our site, such as Gene Expression,Gene Silencing by RNA,PIWI-interacting RNA (piRNA) biogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAEL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Silencing by RNA | MYBL1,TNRC6B,DGCR8,TARBP2,EIF2C3,DDX4,BARHL1,TSN,TSNAX,HENMT1 |
| PIWI-interacting RNA (piRNA) biogenesis | ASZ1,MYBL1,FKBP6,HENMT1,PIWIL4,TDRD1,PLD6,DDX4 |
| Gene Expression | ZNF311,ZNF710,SUPT4H1,HIPK1,ZNF71,DDX6,ESRRG,HNRNPH1L,TBX5,CPSF4 |
Protein Function
MAEL has several biochemical functions, for example, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAEL itself. We selected most functions MAEL had, and list some proteins which have the same functions with MAEL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | ESR2B,RARAB,POU2F2,HOXC11A,ZFP161,EVX2,ZBTB49,VRTN,PAX7A,LHX1A |
Interacting Protein
MAEL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAEL here. Most of them are supplied by our site. Hope this information will be useful for your research of MAEL.
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References
- Lim, SL; Tsend-Ayush, E; et al. Conservation and Expression of PIWI-Interacting RNA Pathway Genes in Male and Female Adult Gonad of Amniotes. BIOLOGY OF REPRODUCTION 89:-(2013).
- Takebe, M; Onohara, Y; et al. Expression of MAEL in nuage and non-nuage compartments of rat spermatogenic cells and colocalization with DDX4, DDX25 and MIWI. HISTOCHEMISTRY AND CELL BIOLOGY 140:169-181(2013).
