MACF1
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Official Full Name
microtubule-actin crosslinking factor 1 -
Overview
The protein encoded by this gene belongs to the plakin family of cytoskeletal linker proteins. This protein family;forms bridges between different cytoskeletal elements through specialized modular domains. The encoded protein is one;of the largest size proteins identified in human cytoskeletal proteins. It has functional actin and microtubule;binding domains, and it appears to stabilize actin at sites where microtubules and microfilaments meet. It may;function in microtubule dynamics to facilitate actin-microtubule interactions at the cell periphery and to couple the;microtubule network to cellular junctions. Alternatively spliced transcript variants encoding distinct isoforms have;been described. -
Synonyms
MACF1;microtubule-actin crosslinking factor 1;microtubule-actin cross-linking factor 1;ABP620;Acf7;Aclp7;Actin cross linking family 7;MACF;Microtubule actin crosslinking factor 1;mKIAA0465;R74989;rabeculin alpha;trabeculin alpha;actin cross-linking family 7;actin-crosslinking protein 7
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MACF1-681H | Recombinant Human MACF1, GST-tagged | E.coli | Human | GST | C-term-303aa |
Involved Pathway
MACF1 involved in several pathways and played different roles in them. We selected most pathways MACF1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MACF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
MACF1 has several biochemical functions, for example, ATPase activity,actin binding,actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MACF1 itself. We selected most functions MACF1 had, and list some proteins which have the same functions with MACF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | ACTN3B,JAG1A,CRP,MBL2,ACTN2,ITSN1,PVALB5,UBE4A,AIF1L,PCDHB15 |
| actin binding | EZR,MYO1H,FSCN1,PAWR,TNS4,CAPZA1B,EPB41L3B,MTSS1L,PHACTR4B,RP2 |
| ATPase activity | NSFB,PSMC1,EIF4A1B,VCP,KIF22,KIF1B,SMARCA4A,ASNA1,KIF21A,KIF4 |
| protein binding | VARS,SPERT,PKM2,STOML1,FGD5,ITGB3BP,CACNG1,SOX15,TTC19,MICALL1 |
| poly(A) RNA binding | NOP14,RPS3,CCDC108,RPL12,DCD,MRPS15,HNRNPC,CHERP,SYNE1,MATR3 |
| microtubule binding | NEIL2,KATNA1,DPYSL2B,HDAC6,TRPV4,CAMSAP2A,KIF4,HAUS8,DYNC1I1,MAP1S |
| actin filament binding | SSFA2,MYO18A,MYH9,TMEM201,LCP1,TRIOBPB,CTNNAL1,MYH9A,TNNC1,SHROOM1 |
Interacting Protein
MACF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MACF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MACF1.
VCAM1;40038273;RAB21;SAP18;MPG;RAB21;JUN;SKIL;APC;MAPK9;ATF7IP;pyrG;q81n36_bacan;q81si6_bacan;DTNBP1;DISC1
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References
- Lu, S; Tian, ZC; et al. Preparation and characterization of the polyclonal antibody against GAR domain of microtubule actin cross-linking factor 1 (MACF1). AFRICAN JOURNAL OF BIOTECHNOLOGY 10:2156-2162(2011).
