LPIN3
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Official Full Name
lipin 3 -
Overview
Humans lipodystrophy is characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mice carrying mutations in the fatty liver dystrophy (fld) gene have similar phenotypes. Through positional cloning, the mouse gene responsible for fatty liver dystrophy was isolated and designated Lpin1. The nuclear protein encoded by Lpin1 was named lipin. Lpin1 mRNA was expressed at high levels in adipose tissue and was induced during differentiation of preadipocytes. These results indicated that lipin is required for normal adipose tissue development and provided a candidate gene for human lipodystrophy. Through database searches, mouse and human EST and genomic sequences with similarities to Lpin1 were identified. These included two related mouse genes (Lpin2 and Lpin3) and three human homologs (LPIN1, LPIN2, and LPIN3). Human LPIN1 gene has been mapped to 2p25.; linkages of fat mass and serum leptin levels to this same region have been noted. Human LPIN2 and LPIN3 mapped to chromosomes 18p11 and 20q11-q12, respectively. The mouse genes encoding Lpin1, Lpin2, and Lpin3 mapped to chromosome 12, 17, and 2, respectively. -
Synonyms
LPIN3;lipin 3;lipin 3 like , LIPN3L;phosphatidate phosphatase LPIN3;SMP2;dJ450M14.2;dJ450M14.3;dJ620E11.2;Lipin 3 like;Lipin-3;Lipin-3-like;Lipin3;LIPN3L;LPIN 3;LPIN3_HUMAN;RP4 620E11.3;lipin 3-like
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LPIN3-4666HCL | Recombinant Human LPIN3 293 Cell Lysate | HEK293 | Human | Non |
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| Lpin3-3812M | Recombinant Mouse Lpin3 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| LPIN3-447H | Recombinant Human LPIN3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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Involved Pathway
LPIN3 involved in several pathways and played different roles in them. We selected most pathways LPIN3 participated on our site, such as Glycerolipid metabolism,Glycerophospholipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPIN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerophospholipid metabolism | DGKD,PEMT,LPCAT2,PCYT1AB,PLA2G1B,PLA2G4C,AGPAT1,PLA2G2D,PCYT1BB,GPCPD1 |
| Metabolic pathways | CYP19A1,CYP2J6,NDUFB7,LASS5,PIGYL,FUT9A,ENPP3,CYP3A5,COX7B2,CECR1A |
| Glycerolipid metabolism | PPAP2C,DGKZ,ALDH9A1,AGPAT1,AKR1A1,PNLIPRP3,AGPAT4,MGLL,LIPF,PNLIPRP2 |
Protein Function
LPIN3 has several biochemical functions, for example, phosphatidate phosphatase activity,transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LPIN3 itself. We selected most functions LPIN3 had, and list some proteins which have the same functions with LPIN3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | KLF7,MAML1,GATA4,TCERG1,MTDH,ATF6,PIAS1,KAT2B,TAF1,PQBP1 |
| phosphatidate phosphatase activity | LPPR3,STIL,PPAP2C,PPAP2CB,LPIN2,LPIN1,PPAPDC1B,PPAPDC1A,PPAP2A,LPPR2 |
Interacting Protein
LPIN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPIN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of LPIN3.
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References
- Avcin, T; Markelj, G; et al. Estimation of antiphospholipid antibodies in a prospective longitudinal study of children with migraine. CEPHALALGIA 24:831-837(2004).
- Lawrence, JC; Lin, TA; et al. Modulation of the protein kinase activity of mTOR. TOR-TARGET OF RAPAMYCIN 279:199-213(2003).
- Huffman, TA; Mothe-Satney, I; et al. Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99:1047-1052(2002).
