LPIN1
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Official Full Name
lipin 1 -
Overview
This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their full-length structures have not been determined. [provided by RefSeq, May 2012] -
Synonyms
LPIN1;lipin 1;PAP1;phosphatidate phosphatase LPIN1;lipin-1
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
- GST
Involved Pathway
LPIN1 involved in several pathways and played different roles in them. We selected most pathways LPIN1 participated on our site, such as Glycerolipid metabolism,Glycerophospholipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPIN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerophospholipid metabolism | GPD1A,PCYT1A,PNPLA7,PISD,PNPLA6,LPCAT2,PTDSS1,LPIN3,ETNPPL,PPAP2A |
| Metabolic pathways | ATP5B,ACSM2,ACOX1,LASS2,CYP26C1,MCCC2,BPNT1,ALAS2,COX4I2,TRIT1 |
| Glycerolipid metabolism | GLYCTK,STIL,ALDH3A2A,LCLAT1,DGKE,GK,AGPAT6,AGPAT3,LIPC,MOGAT1 |
Protein Function
LPIN1 has several biochemical functions, for example, molecular_function,phosphatidate phosphatase activity,transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LPIN1 itself. We selected most functions LPIN1 had, and list some proteins which have the same functions with LPIN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | NXPH3,GOLGA7BA,SDE2,TMEM252,ZBBX,COL6A6,TPRG,WDR27,MFSD11,ASB18 |
| transcription coactivator activity | TAF7,NFE2,ARL2BP,SP100,JUNBB,PQBP1,AIP,NFKB2,MTF1,GMEB2 |
| phosphatidate phosphatase activity | LPIN2,PPAPDC1B,LPIN3,LPPR2,PPAP2A,LPPR3,PPAP2B,STIL,PPAP2C,PPAP2CB |
Interacting Protein
LPIN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPIN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LPIN1.
CDK6;GEMIN5
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References
- Sim, MFM; Talukder, MMU; et al. Analyzing the Functions and Structure of the Human Lipodystrophy Protein Seipin. METHODS OF ADIPOSE TISSUE BIOLOGY, PT A 537:161-175(2014).
- Avcin, T; Markelj, G; et al. Estimation of antiphospholipid antibodies in a prospective longitudinal study of children with migraine. CEPHALALGIA 24:831-837(2004).
- Lawrence, JC; Lin, TA; et al. Modulation of the protein kinase activity of mTOR. TOR-TARGET OF RAPAMYCIN 279:199-213(2003).
