LPAR5
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Official Full Name
lysophosphatidic acid receptor 5 -
Overview
This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described. -
Synonyms
LPAR5;lysophosphatidic acid receptor 5;G protein coupled receptor 92 , GPR92, GPR93;KPG_010;LPA5;LPA-5;LPA receptor 5;G protein-coupled receptor 92;G-protein coupled receptor 92;G-protein coupled receptor 93;GPR92;GPR93
Recombinant Proteins
- Human
- Mus musculus
- Bovine
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LPAR5-2975H | Recombinant Human LPAR5 protein, His-tagged | E.coli | Human | His | 298-372 aa | |
| LPAR5-4723H | Recombinant Human LPAR5 Protein | Wheat Germ | Human | Non |
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| LPAR5-5278H | Recombinant Human LPAR5 Protein, GST-tagged | Wheat Germ | Human | GST |
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| LPAR5-5525HF | Recombinant Full Length Human LPAR5 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 372 amino acids |
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| LPAR5-5972HF | Recombinant Full Length Human LPAR5 Protein | In Vitro Cell Free System | Human | Full L. 295 amino acids |
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| RFL13063HF | Recombinant Full Length Human Lysophosphatidic Acid Receptor 5(Lpar5) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length (1-372) |
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| RFL19986MF | Recombinant Full Length Mouse Lysophosphatidic Acid Receptor 5(Lpar5) Protein, His-Tagged | E.coli | Mus musculus | His | Full L. Full Length (1-372) |
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| RFL24120BF | Recombinant Full Length Bovine Lysophosphatidic Acid Receptor 5(Lpar5) Protein, His-Tagged | E.coli | Bovine | His | Full L. Full Length (1-367) |
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Involved Pathway
LPAR5 involved in several pathways and played different roles in them. We selected most pathways LPAR5 participated on our site, such as Rap signaling pathway,Phospholipase D signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPAR5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | RAC3,MRAS,GNAQ,GNAS,RAC1,PGF,MAPK1,FGF1,PRKCB,CALML3 |
| Phospholipase D signaling pathway | CYTH4,MAP2K1,SOS1,AGPAT4,PPAP2A,GRM4,DGKD,PIK3R5,DNM3,PDGFD |
| PIK-Akt signaling pathway | TEK,ITGB6,PRKAA1,PPP2R5C,CCNE1,FGF13,OSMR,GNG5,PDGFA,IFNB1 |
| Pathways in cancer | CCNE1,BIRC7,CXCL12,RET,PRKACG,GNAS,PLCB1,CXCR4,CBLC,LPAR6 |
Protein Function
LPAR5 has several biochemical functions, for example, G-protein coupled receptor activity,molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by LPAR5 itself. We selected most functions LPAR5 had, and list some proteins which have the same functions with LPAR5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | CRYGM2D11,LMF2B,MSMP,SLC45A4,MESDC2,GM12942,SHISA9A,NUPR1,GM9994,a1BG |
| G-protein coupled receptor activity | CD97,OLFR482,GRM6,NPFFR1L2,CCR7,GPR146,GPR97,LPAR2,GPR34L,TAS2R200.2 |
Interacting Protein
LPAR5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPAR5 here. Most of them are supplied by our site. Hope this information will be useful for your research of LPAR5.
Resources
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References
- Yap, LF; Velapasamy, S; et al. Down-regulation of LPA receptor 5 contributes to aberrant LPA signalling in EBV-associated nasopharyngeal carcinoma. JOURNAL OF PATHOLOGY 235:456-465(2015).
- Dong, Y; Hirane, M; et al. Lysophosphatidic acid receptor-5 negatively regulates cell motile and invasive activities of human sarcoma cell lines. MOLECULAR AND CELLULAR BIOCHEMISTRY 393:17-22(2014).
