LPAR2
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Official Full Name
lysophosphatidic acid receptor 2 -
Overview
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. -
Synonyms
LPAR2;lysophosphatidic acid receptor 2;EDG4, endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 4;EDG 4;LPA2;LPA receptor 2;LPA receptor EDG4;G protein-coupled receptor;lysophosphatidic acid receptor EDG4;lysophosphat
Recombinant Proteins
- Rhesus macaque
- Chicken
- Human
- Mus musculus
- Macaca fascicularis
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- His
- GST
- Non
- Avi
- Fc
Involved Pathway
LPAR2 involved in several pathways and played different roles in them. We selected most pathways LPAR2 participated on our site, such as Rap signaling pathway,Phospholipase D signaling pathway,Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPAR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | RAPGEF6,MLLT4,FGF6,RALGDS,NGFR,FPR1,FGF19,NRAS,SKAP1,PRKCZ |
| Neuroactive ligand-receptor interaction | DRD1A,MC5RB,F2RL3,GABRE,TAAR10A,GRID1,P2RY14,PTGER4A,MTNR1A,CHRNA1 |
| Pathways in cancer | HSP90AB1,WNT1,CDC42,AKT1,AGTR1A,CXCR4,HSP90AA1,MSH3,FLT3,Pdgfa&Pdgfb |
| PIK-Akt signaling pathway | FGF8,IFNAR2,PPP2R5E,PDGFA,LPAR6,PIK3R1,NGFR,ITGA10,FGF1,FLT4 |
| Phospholipase D signaling pathway | SYK,MAPK1,FYN,TSC2,PLA2G4D,MAPK3,PLD1,GNAS,AGPAT4,PLCG2 |
Protein Function
LPAR2 has several biochemical functions, for example, G-protein coupled receptor activity,PDZ domain binding,lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LPAR2 itself. We selected most functions LPAR2 had, and list some proteins which have the same functions with LPAR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZNF223,CRX,SPP1,HLX,RPS6KA4,NRG4,LBP,SPANXC,RASL11A,MB21D2 |
| lipid binding | ATP5G3,APOC2,APOA5,ACOT11B,APOA1A,EPN3,HSP12,PITPNB,ACBD4,CRABP2A |
| G-protein coupled receptor activity | OR12D2,OLFCW1,GPR34A,CELSR3,ADORA2AA,ADRB3A,OR2C1,AVPR2L,MRGPRB2,GPR81 |
| lysophosphatidic acid receptor activity | LPAR2B,LPAR1,LPAR3,LPAR6A,LPAR2A |
| PDZ domain binding | DLC,FZD3,SLC9A3R1,PTEN,GRID2,DLG1,ACCN3,ARHGEF16,NLGN1,PTENA |
Interacting Protein
LPAR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPAR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LPAR2.
CFTR;SLC9A3R2;ATXN1;BCL6
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References
- Kuriyama, S; Theveneau, E; et al. In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity. JOURNAL OF CELL BIOLOGY 206:113-127(2014).
- Purvanov, V; Holst, M; et al. G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion. ELIFE 3:-(2014).
