LPAR1
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Official Full Name
lysophosphatidic acid receptor 1 -
Overview
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG;receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell;signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth;muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two;transcript variants encoding the same protein have been identified for this gene. -
Synonyms
LPAR1;lysophosphatidic acid receptor 1;EDG2, endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 2;edg 2;Gpcr26;GPR26;LPA1;Mrec1.3;rec.1.3;vzg 1;5031439C20;AI326300;Endothelial Cell Differentiation Gene-2;Endothelial differentiation gene 2;Endothelial Differentiation Lysophosphatidic Acid G Protein Coupled Receptor 2;G10 protein homolog;GPCR 26;Gpcr91;Kdt2;LPA 1;LPA receptor 1;LPA receptor EDG2;LPA-1;LPAR1_HUMAN;Lysophosphatidic acid receptor Edg-2;Lysophosphatidic acid receptor EDG2;MGC105279;MGC29102;REC1.3;Ventricular zone gene 1;vzg-1;VZG1;OTTHUMP00000021903;OTTHUMP00000021904;OTTHUMP00000021905;endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2;EDG2;edg-2
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- Mouse
- Bovine
- Mus musculus
- Sheep
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Flag
- His&Fc&Avi
Involved Pathway
LPAR1 involved in several pathways and played different roles in them. We selected most pathways LPAR1 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (i) signalling events,G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPAR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR downstream signaling | ADORA2A,CALCB,DGKA,LPAR2B,ADM2A,RGS12,OXER1,CASR,LPAR5A,FPR-RS3 |
| Class A/1 (Rhodopsin-like receptors) | OXTRL,HCRT,FPR-RS3,CXCL11.8,NPFF,EDNRA,ADRB2,ACKR4,OPN1LW1,PROKR1A |
| Gap junction | TUBA3B,DRD1B,MAP2K2A,MAP2K2B,TUBA3E,TUBA4A,RAF1A,MAPK7,KRAS,PRKCBB |
| G alpha (i) signalling events | RGS4,OPN1MW2,OXGR1A.3,HEBP1,TAS2R7,NPB,SSTR4,SSTR1,RLN3,SSTR2 |
| LPA receptor mediated events | GNA13 |
| Gastrin-CREB signalling pathway via PKC and MAPK | QRFP,ABHD12,TAC2,LTB4R,EDNRAB,OPN4.1,TRPC6A,NPFF,EDN1,OPN4A |
| G alpha (q) signalling events | EDN2,FPR-RS6,CHRM1,FPR-RS3,OPN4,OPN4A,OPN4B,NTS,OPN4.1,MLN |
| GPCR ligand binding | CCR7,OXGR1A.3,ADORA3,EMR4,MLN,PPY,OPN1MW2,EDNRAB,OPN1LW1,GPR65 |
Protein Function
LPAR1 has several biochemical functions, for example, G-protein alpha-subunit binding,G-protein coupled receptor activity,PDZ domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LPAR1 itself. We selected most functions LPAR1 had, and list some proteins which have the same functions with LPAR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lysophosphatidic acid receptor activity | LPAR6A,LPAR2A,LPAR3,LPAR2B,LPAR2 |
| lysophosphatidic acid binding | GAP43,VIL1 |
| G-protein alpha-subunit binding | HTR2A,DRD1A,NUCB1,OPRM1,DRD1,HTR2B,ARHGEF11,RIC8B,AGTR1A,LPAR3 |
| protein binding | SSX5,HINFP,SMU1,VPS11,COMMD5,LOXL3,SEPHS1,FAM206A,RITA1,CD300LG |
| G-protein coupled receptor activity | OLFR473,S1PR1,OR4D2,CCR1L1,OLFR10,CALCRL,GPR128,LPAR6A,GPR68,TAS2R109 |
| PDZ domain binding | ATP2B2,ATP2B1A,GRIK5,CXADR,TBC1D10A,CIT,ARHGAP29,ACCN3,KIDINS220B,SLC26A6 |
Interacting Protein
LPAR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPAR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LPAR1.
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References
- Ryu, JM; Han, HJ; et al. Autotaxin-LPA Axis Regulates hMSC Migration by Adherent Junction Disruption and Cytoskeletal Rearrangement Via LPAR1/3-Dependent PKC/GSK3 beta/beta-Catenin and PKC/Rho GTPase Pathways. STEM CELLS 33:819-832(2015).
- Wu, L; Petrigliano, FA; et al. Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis. OSTEOARTHRITIS AND CARTILAGE 23:308-318(2015).
