LOXL4
-
Official Full Name
lysyl oxidase-like 4 -
Overview
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008] -
Synonyms
LOXL4;lysyl oxidase-like 4;LOXC;lysyl oxidase homolog 4;lysyl oxidase related C;lysyl oxidase-like protein 4;lysyl oxidase-like 4 pseudogene;lysyl oxidase-related protein C
Recombinant Proteins
- Human
- Mouse
- E.coli
- Insect Cell
- Wheat Germ
- HEK293
- Yeast
- In Vitro Cell Free System
- His
- GST
- FLAG
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LOXL4-280H | Recombinant Human LOXL4 Protein, His-tagged | E.coli | Human | His | Gly399~Pro552 | |
| LOXL4-194H | Recombinant Human LOXL4 protein, GST-tagged | Insect Cell | Human | GST | 492-end |
|
| LOXL4-2157H | Recombinant Human LOXL4 protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| LOXL4-2158H | Recombinant Human LOXL4 protein, His-tagged | E.coli | Human | His | 570-756 a.a. |
|
| LOXL4-2159H | Recombinant Human LOXL4 protein, FLAG-tagged | Insect Cell | Human | FLAG |
|
|
| LOXL4-28220TH | Recombinant Human LOXL4 | Human | Non | 500-756 a.a. |
|
|
| LOXL4-4676HCL | Recombinant Human LOXL4 293 Cell Lysate | HEK293 | Human | Non |
|
|
| Loxl4-1742M | Recombinant Mouse Loxl4 Protein, His-tagged | E.coli | Mouse | His | Pro534-Ser737 |
|
| LOXL4-2001M | Recombinant Mouse LOXL4 Protein (26-757 aa), His-tagged | E.coli | Mouse | His | 26-757 aa |
|
| LOXL4-2020M | Recombinant Mouse LOXL4 Protein (26-757 aa), His-tagged | Yeast | Mouse | His | 26-757 aa |
|
| LOXL4-4705H | Recombinant Human LOXL4 protein, His-tagged | E.coli | Human | His | 25-756aa |
|
| LOXL4-5209H | Recombinant Human LOXL4 Protein (Gly399-Pro552), His tagged | E.coli | Human | His | Gly399-Pro552 |
|
| LOXL4-577HF | Recombinant Full Length Human LOXL4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 756 amino acids |
|
Involved Pathway
LOXL4 involved in several pathways and played different roles in them. We selected most pathways LOXL4 participated on our site, such as Assembly of collagen fibrils and other multimeric structures,Collagen formation,Crosslinking of collagen fibrils, which may be useful for your reference. Also, other proteins which involved in the same pathway with LOXL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Extracellular matrix organization | COL5A1,MATN4,MFAP2,LEPRE1,CTS7,COL23A1,SERPINH1B,NID2,TTR,F11R.2 |
| Collagen formation | COL13A1,COL3A1,TLL2,CTSL2,MMP20,COL19A1,PRP,COL5A3A,LEPREL2,COL11A1B |
| Assembly of collagen fibrils and other multimeric structures | TLL1,CTSL2,COL5A3B,COL1A2,COL8A2,MMP13,COL5A2,LOX,CTSL1,BMP1B |
| Crosslinking of collagen fibrils | LOXL1,BMP1B,ABHD1,PCOLCE,LOX,BMP1,TLL2,TLL1,LOXL3,LOXL2 |
| Elastic fibre formation | ITGB3A,MFAP4,LOXL2,LTBP2,EFEMP1,FURINA,MFAP2,LOXL1,FBLN1,ABHD1 |
Protein Function
LOXL4 has several biochemical functions, for example, copper ion binding,protein binding,protein-lysine 6-oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LOXL4 itself. We selected most functions LOXL4 had, and list some proteins which have the same functions with LOXL4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| copper ion binding | LOXL3B,DCT,SNAI3,COX17,HEPHL1,S100V2,COX11,ADNP,METTL17,APOA4 |
| protein binding | CREB3L1,ARAP1,DHX40,SLAMF1,SIGIRR,PHOSPHO2-KLHL23,RPS19BP1,SMAD1,SMURF2,USP37 |
| protein-lysine 6-oxidase activity | LOXL2B,ABHD1,LOX,LOXL3,LOXL2,POLR1B,LOXL2A |
| scavenger receptor activity | CD163L1,PRG4A,PGBD1,HHIPL1,MSR1,TMPRSS15,LOXL3,ACKR4,CFI,LGALS3BPA |
Interacting Protein
LOXL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LOXL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of LOXL4.
TRIP13;KDM1A;PRMT6;SUV39H1;APOE;LONP1;RAD23A;CDC37;EXOC6;ECSIT;MAST1
Resources
Related Services
Related Products
References