LOXL1
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Official Full Name
lysyl oxidase-like 1 -
Overview
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008] -
Synonyms
LOXL1;lysyl oxidase-like 1;LOL;LOXL;lysyl oxidase homolog 1;lysyl oxidase-like protein 1
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- Sf9 Cells
- Mammalian Cells
- Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&T7
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LOXL1-268H | Recombinant Human LOXL1 Protein, His-tagged | E.coli | Human | His | Leu369~Ser574 | |
| LOXL1-2696H | Recombinant Human LOXL1 protein, His-tagged | E.coli | Human | His | 283-366 aa | |
| Loxl1-270M | Recombinant Mouse Loxl1 Protein, His-tagged | E.coli | Mouse | His | Val392~Ser598 | |
| Loxl1-271R | Recombinant Rat Loxl1 Protein, His-tagged | E.coli | Rat | His | Val393~Cys603 | |
| LOXL1-149H | Recombinant Human LOXL1, GST-tagged | Sf9 Cells | Human | GST | 292-end a.a. |
|
| LOXL1-3850Z | Recombinant Zebrafish LOXL1 | Mammalian Cells | Zebrafish | His |
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| LOXL1-9185M | Recombinant Mouse LOXL1 Protein | Mammalian Cells | Mouse | His |
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| LOXL1-1028HCL | Recombinant Human LOXL1 cell lysate | Human | Non |
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| LOXL1-1446M | Recombinant Mouse LOXL1 Protein (95-607 aa), His-tagged | Yeast | Mouse | His | 95-607 aa |
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| LOXL1-28H | Recombinant Human LOXL1 Protein, T7-His-tagged | E.coli | Human | His&T7 |
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| LOXL1-3181H | Recombinant Human LOXL1 protein, His-tagged | E.coli | Human | His | 106-574aa |
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| LOXL1-3182H | Recombinant Human LOXL1 protein | E.coli | Human | Non | 95-574aa |
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| LOXL1-4732H | Recombinant Human LOXL1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| LOXL1-5131M | Recombinant Mouse LOXL1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| LOXL1-5131M-B | Recombinant Mouse LOXL1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| LOXL1-5964HF | Recombinant Full Length Human LOXL1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 574 amino acids |
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| LOXL1-629M | Recombinant Mouse LOXL1 Protein (95-607 aa), His-tagged | E.coli | Mouse | His | 95-607 aa |
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Involved Pathway
LOXL1 involved in several pathways and played different roles in them. We selected most pathways LOXL1 participated on our site, such as Assembly of collagen fibrils and other multimeric structures,Collagen formation,Crosslinking of collagen fibrils, which may be useful for your reference. Also, other proteins which involved in the same pathway with LOXL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Elastic fibre formation | FBLN1,LOX,LTBP2,ABHD1,MFAP2,LTBP3,LOXL2,FBLN2,MFAP3,FBN2 |
| Crosslinking of collagen fibrils | ABHD1,LOXL3,BMP1B,BMP1A,LOXL2,BMP1,PCOLCE,TLL1,LOXL4,LOX |
| Extracellular matrix organization | TIMP2A,TLL1,MFAP2,CTSK,ELANE,COL5A1,ADAMTS4,BMP1A,COL19A1,CTSLL |
| Assembly of collagen fibrils and other multimeric structures | BMP1B,COL8A1A,MMP20,CTSL1,TLL1,COL6A3,COL1A2,COL4A4,CTSL2,BMP1 |
| Collagen formation | COL1A1,ADAMTS3,LOXL3,COL11A1B,COL8A2,CTSB,EMID2,COL9A1,PCOLCEB,COL8A1A |
Protein Function
LOXL1 has several biochemical functions, for example, copper ion binding,oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by LOXL1 itself. We selected most functions LOXL1 had, and list some proteins which have the same functions with LOXL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor | LOXL2B,LOXL5A,LOXL5B,LOXL3A,LOXL3B,LOXL2A |
| copper ion binding | TYRP1B,F8,LOXL4,SCO2,CP,CUTC,HAMP,ATOX1,ADNP,PARK7 |
Interacting Protein
LOXL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LOXL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LOXL1.
FBLN5;GATAD2B;TFAP2A;ATXN1;TFAP2C
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References
- Creasey, R; Sharma, S; et al. Atomic force microscopy-based antibody recognition imaging of proteins in the pathological deposits in Pseudoexfoliation Syndrome. ULTRAMICROSCOPY 111:1055-1061(2011).
- Kumarasamy, A; Schmitt, I; et al. Lysyl Oxidase Activity Is Dysregulated during Impaired Alveolarization of Mouse and Human Lungs. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 180:1239-1252(2009).
- Fujimoto, E; Tajima, S; et al. Reciprocal regulation of LOX and LOXL2 expression during cell adhesion and terminal differentiation in epidermal keratinocytes. JOURNAL OF DERMATOLOGICAL SCIENCE 55:91-98(2009).
- Pascual, G; Mendieta, C; et al. Down-regulation of lysyl oxydase-like in aging and venous insufficiency. HISTOLOGY AND HISTOPATHOLOGY 23:179-186(2008).
