LLGL1
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Official Full Name
lethal giant larvae homolog 1 -
Overview
LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17. LLGL2 is a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. -
Synonyms
LLGL1 + LLGL2;DLG4;HGL;HUGL;HUGL 1;HUGL1;Human homolog to the D lgl gene protein;lethal giant larvae homolog 1;lethal giant larvae homolog 2;Lethal(2) giant larvae protein homolog 1;Lethal(2) giant larvae protein homolog 2;LGL2;LLGL
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- Wheat Germ
- Mammalian Cells
- HEK293
- Non
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LLGL1-28095TH | Recombinant Human LLGL1 | Wheat Germ | Human | Non | 100 amino acids |
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| LLGL1-3422R | Recombinant Rat LLGL1 Protein | Mammalian Cells | Rat | His |
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| LLGL1-4410Z | Recombinant Zebrafish LLGL1 | Mammalian Cells | Zebrafish | His |
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| LLGL1-9140M | Recombinant Mouse LLGL1 Protein | Mammalian Cells | Mouse | His |
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| LLGL1-3078R | Recombinant Rat LLGL1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| LLGL1-3078R-B | Recombinant Rat LLGL1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| LLGL1-5106M | Recombinant Mouse LLGL1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| LLGL1-5106M-B | Recombinant Mouse LLGL1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
LLGL1 involved in several pathways and played different roles in them. We selected most pathways LLGL1 participated on our site, such as Hippo signaling pathway,Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LLGL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tight junction | MYH1A,CLDND,ACTN2B,ACTN3A,MYHZ2,MYH15,MYH3,ACTN2,OCLNA,MAGI1 |
| Hippo signaling pathway | YWHAE,WNT3A,AXIN2,BMPR1B,BMP5,SMAD4,AREG,GLI2,BMP8B,SMAD2 |
Protein Function
LLGL1 has several biochemical functions, for example, GTPase activator activity,Rab GTPase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LLGL1 itself. We selected most functions LLGL1 had, and list some proteins which have the same functions with LLGL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | SPAG16,HSPB1,IL31RA,FGFR1OP,CAMK2N2,VRK1,DNAJA3,MSH2,CEP68,KIF14 |
| structural molecule activity | TUBA1C,KRT42,PRPH,KRT1-C5,KRT81,LAMA3,SPRR1B,KRTAP11-1,COPE,KLHL3 |
| GTPase activator activity | RAP1GAP,STARD8,ARHGAP29,ARHGEF1,RASAL1,PLEKHG6,ARHGAP29B,CDC42EP3,ARHGAP26,ARHGDIA |
| NOT syntaxin binding | C2CD4B,TC2N,C2CD4A,LLGL2 |
| Rab GTPase binding | ULK1,MYO5B,RPH3A,MICAL1,RAB11FIP5,STXBP5A,RAB11FIP4,CFAP45,EVI5,BICD1 |
| protein binding | GPR125,HHIPL2,DHX58,BLOC1S3,ZNF652,ANP32B,AGL,SLC52A2,SSSCA1,BAI3 |
Interacting Protein
LLGL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LLGL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LLGL1.
PRKCI;PARD6B;SQSTM1;KBTBD7;PRKCZ;PARD6G;PARD6A;TIMM13
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References
- Wang, M; Meng, JY; et al. Xihuang Pill induces mesenchymal-epithelial transition and inhibits loss of apical-basal polarity in colorectal cancer cell through regulating ZEB1-SCRIB Loop. CHINESE JOURNAL OF INTEGRATIVE MEDICINE 20:751-757(2014).
- Jagut, M; Mihaila-Bodart, L; et al. A Mosaic Genetic Screen for Genes Involved in the Early Steps of Drosophila Oogenesis. G3-GENES GENOMES GENETICS 3:409-425(2013).
