LIN7B

  • Official Full Name

    lin-7 homolog B

  • Overview

    Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface.

  • Synonyms

    LIN7B;lin-7 homolog B (C. elegans);protein lin-7 homolog B;LIN 7B;MALS 2;VELI2;hLin7B;hVeli2;veli-2;vertebrate lin-7 homolog 2;mammalian lin-seven protein 2;MALS2;LIN-7B;MALS-2

Recombinant Proteins

  • Rhesus macaque
  • Chicken
  • Zebrafish
  • Rat
  • Human
  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • His&Fc&Avi
  • Myc&DDK

    Involved Pathway

    LIN7B involved in several pathways and played different roles in them. We selected most pathways LIN7B participated on our site, such as Dopamine Neurotransmitter Release Cycle,Neuronal System,Neurotransmitter Release Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIN7B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Transmission across Chemical Synapses PICK1,DLG1L,SYT1A,CACNB4B,ARL6IP5B,SYN1,SLC1A2A,CAMKK1B,LIN7A,HAND2
    Neurotransmitter Release Cycle SLC17A7A,ARL6IP5,RERG,SYN1,CPLX1,SLC6A11,SNAP25B,STXBP1A,SLC18A3A,ARL6IP5A
    RHO GTPases Activate Rhotekin and Rhophilins RHPN1,ROPN1,RHOC,TAX1BP3,RHPN2,RTKN
    Neuronal System SLC17A7A,PANX1,KCNK4,KCNH1B,KCNMB2,KCNC2,SNAP25B,KCNMB1,SLC1A3A,KCNK2B
    Signal Transduction FSTL1,METAP1,CDON,CSN2,DEPDC7,OXGR1A.2,GRK7,CALML4,TLE3B,DZIP1
    Signaling by Rho GTPases ARHGAP31,CIT,ARHGAP28,STARD13,ARHGAP29B,CHN2,TAGAPA,KIF14,ARHGAP11A,DLC1
    Dopamine Neurotransmitter Release Cycle PPFIA2,UNC13B,Apba1,PPFIA4,LIN7C,LIN7A,SYN1,RERG,SYN3,CCDC167
    RHO GTPase Effectors SPC25,ROPN1,CIT,NDEL1A,RTKN,PRC1B,NUF2,FMNL1,ABI1A,CLIP1

    Protein Function

    LIN7B has several biochemical functions, for example, L27 domain binding,PDZ domain binding,protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIN7B itself. We selected most functions LIN7B had, and list some proteins which have the same functions with LIN7B. You can find most of the proteins on our site.

    Function Related Protein
    protein domain specific binding MTOR,PLXND1,GABRR3,PRKAR2B,SP100,CHMP2A,DBNL,NR0B1,COX4I2,ANGEL1
    PDZ domain binding KIF14,ARHGAP29,GRIK2,ACCN3,KIDINS220B,F11R,KIDINS220,LRP2,FZD1,USHBP1
    L27 domain binding LIN7A,LIN7C,DLG1

    Interacting Protein

    LIN7B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIN7B here. Most of them are supplied by our site. Hope this information will be useful for your research of LIN7B.

    KCNJ4;ABCA1

    Resources

    References

    • Mizuno, M; Matsumoto, A; et al. Role of an adaptor protein Lin-7B in brain development: possible involvement in autism spectrum disorders. JOURNAL OF NEUROCHEMISTRY 132:61-69(2015).
    • Kultima, K; Jergil, M; et al. Early transcriptional responses in mouse embryos as a basis for selection of molecular markers predictive of valproic acid teratogenicity. REPRODUCTIVE TOXICOLOGY 30:457-468(2010).

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