LIMS2
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Official Full Name
LIM and senescent cell antigen-like domains 2 -
Overview
LIMS2 is a focal adhesion protein that associates with integrin-linked kinase (ILK; MIM 602366), a multidomain protein that mediates multiple protein-protein interactions at adhesion sites between cells and the extracellular matrix (ECM). -
Synonyms
LIMS2;LIM and senescent cell antigen-like domains 2;LIM and senescent cell antigen-like-containing domain protein 2;FLJ10044;LIM-like protein 2;LIMS2_HUMAN;Particularly interesting new Cys-His protein 2;PINCH-2;ILK-binding protein;PINCH2
Recombinant Proteins
- Rhesus macaque
- Zebrafish
- Mouse
- Mammalian Cells
- HEK293
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LIMS2-2520R | Recombinant Rhesus monkey LIMS2 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| LIMS2-2836Z | Recombinant Zebrafish LIMS2 | Mammalian Cells | Zebrafish | His |
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| LIMS2-9111M | Recombinant Mouse LIMS2 Protein | Mammalian Cells | Mouse | His |
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| LIMS2-2340R | Recombinant Rhesus Macaque LIMS2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| LIMS2-2340R-B | Recombinant Rhesus Macaque LIMS2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| LIMS2-5088M | Recombinant Mouse LIMS2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| LIMS2-5088M-B | Recombinant Mouse LIMS2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
LIMS2 involved in several pathways and played different roles in them. We selected most pathways LIMS2 participated on our site, such as PodNet: protein-protein interactions in the podocyte,XPodNet - protein-protein interactions in the podocyte expanded by STRING, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIMS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PodNet: protein-protein interactions in the podocyte | DDN,FAM65A,FRAS1,SDK1,CMIP,TENC1 |
| XPodNet - protein-protein interactions in the podocyte expanded by STRING | CMIP,Siglece,GJB6,GMCL1,O3far1,FLII,ARHGAP32,Ighg,SDK1,DDN |
Protein Function
LIMS2 has several biochemical functions, for example, metal ion binding,molecular_function,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIMS2 itself. We selected most functions LIMS2 had, and list some proteins which have the same functions with LIMS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ZNF865,USP2,ZNF239,PAPOLG,PPP6C,ZFP184,FTR43,ZBTB18,TPH1A,EXT1 |
| zinc ion binding | SHPRH,CAR13,RNF175,TRIM69,DTX1,ADH4,RNPEP,ENPP2,LMX1BB,PITRM1 |
| molecular_function | CASKIN2,TTLL9,TSPAN7B,RPZ4,GPM6BA,FAM19A4B,CFHL1,GKN1,SHISA9B,GM15308 |
Interacting Protein
LIMS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIMS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LIMS2.
Resources
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References
- Uribe, V; Badia-Careaga, C; et al. Arid3b is essential for second heart field cell deployment and heart patterning. DEVELOPMENT 141:4168-4181(2014).
- Haam, K; Kim, HJ; et al. Epigenetic silencing of BTB and CNC homology 2 and concerted promoter CpG methylation in gastric cancer. CANCER LETTERS 351:206-214(2014).
