LIMA1
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Official Full Name
LIM domain and actin binding 1 -
Overview
This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. -
Synonyms
LIMA1;LIM domain and actin binding 1;LIM domain and actin-binding protein 1;epithelial protein lost in neoplasm beta;EPLIN;1110021C24Rik;sterol regulatory element binding protein 3;SREBP3;FLJ38853;MGC131726
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LIMA1-584H | Recombinant Human LIMA1, GST-tagged | E.coli | Human | GST | C-term-400aa | |
| LIMA1-4020H | Recombinant Human LIMA1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| LIMA1-9194Z | Recombinant Zebrafish LIMA1 | Mammalian Cell | Zebrafish | His |
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| LIMA1-4742HCL | Recombinant Human LIMA1 293 Cell Lysate | HEK293 | Human | Non |
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| LIMA1-4691HF | Recombinant Full Length Human LIMA1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 598 amino acids |
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Involved Pathway
LIMA1 involved in several pathways and played different roles in them. We selected most pathways LIMA1 participated on our site, such as Stabilization and expansion of the E-cadherin adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIMA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Stabilization and expansion of the E-cadherin adherens junction | KIFC3,MYO6,LPP,PLEKHA7 |
Protein Function
LIMA1 has several biochemical functions, for example, actin filament binding,actin monomer binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIMA1 itself. We selected most functions LIMA1 had, and list some proteins which have the same functions with LIMA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin filament binding | MYH11,MYO18A,EGFR,TNNC1,CORO1CA,MYH9A,ARPC1A,ADD2,CAPZB,DBNL |
| protein binding | EMP3,NFE2L3,CDR2,RAB7,KRT80,NFKBIA,ATP6V0A2,UNC119,EWSR1,OTUD7B |
| actin monomer binding | LMOD3,CORO1A,MTSS1,MKL1,TMSB15B,MYL4,COBLL1,TMSB4Y,ABL2,PFN1 |
| zinc ion binding | BTR09,IDE,AMZ2,RNF10,PHF19,PDZRN3B,SIAH1A,NR4A2,GM3258,EWSR1 |
Interacting Protein
LIMA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIMA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LIMA1.
SVIL;YWHAZ;dAK1_1;PLEKHG3;b4e2v5_human;RPSA;midostaurin;DST;PICALM;SEC16A;ACTG1;PDLIM1;MYO1C;MYO1C;PIK3C2A;Flot1;ABLIM1;GAK
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References
- Ohoka, A; Kajita, M; et al. EPLIN is a crucial regulator for extrusion of RasV12-transformed cells. JOURNAL OF CELL SCIENCE 128:781-789(2015).
- Nie, ZL; Du, MQ; et al. Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma. Nature Communications 6:-(2015).
