LGR4

  • Official Full Name

    leucine-rich repeat containing G protein-coupled receptor 4

  • Overview

    G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich;GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain;(Weng et al., 2008 (PubMed 18424556)).

  • Synonyms

    LGR4;leucine-rich repeat containing G protein-coupled receptor 4;G protein coupled receptor 48 , GPR48, leucine rich repeat containing G protein coupled receptor 4;leucine-rich repeat-containing G-protein coupled receptor 4;G protein-coupled receptor

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Rat
  • Mouse
  • HEK293
  • Mammalian Cell
  • E.coli
  • Mammalian cells
  • Non
  • His
  • His&Fc&Avi
  • Fc

    Involved Pathway

    LGR4 involved in several pathways and played different roles in them. We selected most pathways LGR4 participated on our site, such as Odorant GPCRs,Regulation of FZD by ubiquitination,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LGR4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Odorant GPCRs V1RA8,GPR173,VMN1R52,VMN2R26,VMN1R43,VMN1R45,GPR133,GPR108,OLFR476,MRGPRB5
    Signaling by Wnt SOX32,HECW1B,PRICKLE1B,RNF43,PRICKLE1,KREMEN2,SOX4B,WNT8-2,SRY,WIF1
    TCF dependent signaling in response to WNT RBBP5,LGR6,SOX32,TNKS,RSPO4,LGR5,SOX6,BCL9,HECW1,WIF1
    Signal Transduction FGFBP2,SH2B3,CRHB,FSTB,CUL5A,RLBP1B,AMOTL2,PROKR1A,KAL1,GDI1
    Regulation of FZD by ubiquitination FMNL3,RSPO1,LGR6,RSPO2,RSPO4,RSPO3,RNF43,LGR5,ZNRF3

    Protein Function

    LGR4 has several biochemical functions, for example, NOT G-protein coupled receptor activity,protein binding,protein-hormone receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LGR4 itself. We selected most functions LGR4 had, and list some proteins which have the same functions with LGR4. You can find most of the proteins on our site.

    Function Related Protein
    protein-hormone receptor activity RXFP2,GNRHR4,GNRHR3,GNRHR2,GNRHR1
    protein binding SGCG,SMC1A,TCEANC2,CCNDBP1,SEC23IP,MEP1B,AGBL1,KRTAP2-3,UFC1,SRA1
    signal transducer activity MRGPRB8,MRGPRG,TAAR9,OLFR154,OLFR510,TMTOPS2B,OLFCQ19,PTGER1C,HTR1D,GNB2
    transmembrane signaling receptor activity TLR3,TLR18,CD247,CD3E,TRPV1,KIR2DS2,P2RX5,GPR182,GPR133,RYK
    NOT G-protein coupled receptor activity SFRP4,SFRP1A,LGR5,SFRP1,LGR6,SFRP2,FRZB,SZL,SFRP1B

    Interacting Protein

    LGR4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LGR4 here. Most of them are supplied by our site. Hope this information will be useful for your research of LGR4.

    LGR4 Related Signal Pathway

    Resources

    References

    • Snyder, JC; Rochelle, LK; et al. Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions. JOURNAL OF CELL SCIENCE 128:1230-1240(2015).
    • Liang, F; Yue, JM; et al. GPCR48/LGR4 promotes tumorigenesis of prostate cancer via PI3K/Akt signaling pathway. MEDICAL ONCOLOGY 32:-(2015).

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