lgfbp4
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Official Full Name
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Overview
Insulin-like growth factor binding protein 4 (IGFBP4), is one of the six Insulin-like growth factor-binding proteins (IGFBPs) , that control bioavailability, activity, and distribution of insulin-like growth factor (IGF)1 and 2 through high-affinity IGFBP/IGF interactions. Despite their structural similarity,each IGFBPs has unique properties and exhibits specific functions. IGFBP4 has an IGFBP domain and a thyroglobulin type-I domain. It binds IGFs and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. It is suggested that IGFBP4 is a unique protein in that it consistently inhibits several cancer cells in vivo and in vitro through a mechanism dependent or independent of IGFs. Overexpression of IGFBP4 in transgenic animal models causes reduced growth of organs containing smooth muscle. -
Synonyms
insulin-like growth factor binding protein 4;Deb2;IGFBP-4;AI875747;Igfbp4;Band 3A;OTTMUSP00000006838;differentially expressed in B16F10 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| lgfbp4-760M |
Active Recombinant Mouse lgfbp4 protein, His-tagged
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HEK293 | Mouse | His | Met1-Glu254 |
Involved Pathway
lgfbp4 involved in several pathways and played different roles in them. We selected most pathways lgfbp4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with lgfbp4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
lgfbp4 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by lgfbp4 itself. We selected most functions lgfbp4 had, and list some proteins which have the same functions with lgfbp4. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
lgfbp4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with lgfbp4 here. Most of them are supplied by our site. Hope this information will be useful for your research of lgfbp4.
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