LEPREL2
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Official Full Name
leprecan-like 2 -
Overview
LEPREL2 belongs to a family of collagen prolyl hydroxylases required for proper collagen biosynthesis, folding, and;assembly (Vranka et al., 2004 (PubMed 15044469)). -
Synonyms
LEPREL2;leprecan-like 2;prolyl 3-hydroxylase 3;GRCB;HSU47926;P3H3;prolyl 3 hydroxylase 3;B protein;protein B;gene rich cluster, B;leprecan-like 2 protein;leprecan-like protein 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LEPREL2-548H | Recombinant Human LEPREL2, His-tagged | E.coli | Human | His | C-term-383aa | |
| LEPREL2-9052M | Recombinant Mouse LEPREL2 Protein | Mammalian Cells | Mouse | His |
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| LEPREL2-5045M | Recombinant Mouse LEPREL2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| LEPREL2-5045M-B | Recombinant Mouse LEPREL2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
LEPREL2 involved in several pathways and played different roles in them. We selected most pathways LEPREL2 participated on our site, such as Collagen biosynthesis and modifying enzymes,Collagen formation,Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEPREL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Collagen biosynthesis and modifying enzymes | PPIB,BMP1B,COL11A1B,COL19A1,COL28A1,COL13A1,PCOLCE2,COL5A2,COL10A1A,PRP |
| Collagen formation | SERPINH1A,EMID2,COL6A3,COL8A2,COL25A1,COL15A1B,ADAMTS3,LOXL1,PCOLCE2,COL28A1 |
| Extracellular matrix organization | COL9A1,ADAM8,COL19A1,HAPLN1,MMP15,ADAM15,TLDC2,PCOLCE2B,LRP4,DDR2 |
Protein Function
LEPREL2 has several biochemical functions, for example, L-ascorbic acid binding,iron ion binding,procollagen-proline 3-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LEPREL2 itself. We selected most functions LEPREL2 had, and list some proteins which have the same functions with LEPREL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| procollagen-proline 3-dioxygenase activity | P3H2,LEPRE1,LEPREL1 |
| L-ascorbic acid binding | EGLN1,OGFOD2,PAM,EGLN2,P4HA2,PLOD1,P4HA1,TMLHE,P4HA3,P4HA1A |
| iron ion binding | CYP2X9,CYP46A1.3,CYP2A12,CYP3A25,HBAE1,CYP2S1,ALKBH8,ALOX5B.3,CYP2AD3,CYP4X1 |
Interacting Protein
LEPREL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEPREL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEPREL2.
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References
- Hatzimichael, E; Lo Nigro, C; et al. The collagen prolyl hydroxylases are novel transcriptionally silenced genes in lymphoma. BRITISH JOURNAL OF CANCER 107:1423-1432(2012).
