LEPRE1
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Official Full Name
leucine proline-enriched proteoglycan (leprecan) 1 -
Overview
This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Three alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined. -
Synonyms
LEPRE1;leucine proline-enriched proteoglycan (leprecan) 1;prolyl 3-hydroxylase 1;GROS1;growth suppressor 1;LEPRECAN;MGC117314;P3H1;prolyl 3 hydroxylase 1;leucine- and proline-enriched proteoglycan 1;OI8
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
Involved Pathway
LEPRE1 involved in several pathways and played different roles in them. We selected most pathways LEPRE1 participated on our site, such as Collagen biosynthesis and modifying enzymes,Collagen formation,Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with LEPRE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Extracellular matrix organization | COL28A1,MFAP3,DST,DAG1,MFAP4,FURINA,CEACAM8,MMP20,EMID2,LEPREL1 |
| Collagen biosynthesis and modifying enzymes | COL5A1,BMP1B,PCOLCE,COL5A2,COL4A4,COL13A1,COL6A3,LEPREL2,COL28A1,COL16A1 |
| Collagen formation | COL19A1,COL9A1B,COL8A1,COL5A2,COL4A3,COL8A1A,BMP1A,PCOLCEA,CD151,PRP |
Protein Function
LEPRE1 has several biochemical functions, for example, L-ascorbic acid binding,contributes_to collagen binding,iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LEPRE1 itself. We selected most functions LEPRE1 had, and list some proteins which have the same functions with LEPRE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron ion binding | CYP2P8,HBZ,AOX4,FTL,SCD,HBG1,TET1,HBA-X,EGLN1,CYP4F18 |
| protein complex binding | THRA,ATF1,PPP1R9B,Cel,Apba1,KRIT1,IGBP1,INS2,NFYB,GNB1 |
| molecular_function | DEFA24,SPECC1LA,TVP23B,UBTD1A,BCAS3,PRL8A8,PWWP2A,FETUB,SIPA1L1,KRTAP6-5 |
| contributes_to collagen binding | PPIB |
| procollagen-proline 3-dioxygenase activity | LEPREL2,LEPREL1,P3H2 |
| L-ascorbic acid binding | PLOD1,LEPREL2,EGLN3,P4HTM,OGFOD3,EGLN2,PLOD1A,LEPREL1,P3H2,P4HA1A |
Interacting Protein
LEPRE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LEPRE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LEPRE1.
Sf3a1;WDR48;Mtx1;SEC16A;NUDT21;KIF21B;VPS26A;MED26;MYC;cona_canen;Sod1;H2AFX;SNCA;CDK18;RNPS1;Srsf1;Smad3;CEP170P1;MAP1LC3B;Sart3
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References
- Rubinato, E; Morgan, A; et al. A novel deletion mutation involving TMEM38B in a patient with autosomal recessive osteogenesis imperfecta. GENE 545:290-292(2014).
- Rauch, F; Lalic, L; et al. Targeted Sequencing of a Pediatric Metabolic Bone Gene Panel Using a Desktop Semiconductor Next-Generation Sequencer. CALCIFIED TISSUE INTERNATIONAL 95:323-331(2014).
