LDB3
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Official Full Name
LIM domain binding 3 -
Overview
This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains. -
Synonyms
LDB3;LIM domain binding 3;LIM domain-binding protein 3;cypher;KIAA0613;oracle;PDLIM6;ZASP;CMD1C;HGNC:15710;KIAA01613;LDB3_HUMAN;LDB3Z1;LIM domain binding protein 3;LVNC3;PDZ and LIM domain 6;Protein cypher;Z band alternatively spliced PDZ motif;Z band alternatively spliced PDZ motif protein;Z-band alternatively spliced PDZ-motif protein;OTTHUMP00000020008;OTTHUMP00000020009;LDB3Z4
Recombinant Proteins
- Chicken
- Mouse
- Human
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- Myc&DDK
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LDB3-5478C | Recombinant Chicken LDB3 | Mammalian Cells | Chicken | His |
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| LDB3-9019M | Recombinant Mouse LDB3 Protein | Mammalian Cells | Mouse | His |
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| LDB3-977HCL | Recombinant Human LDB3 cell lysate | Human | Non |
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| LDB3-1539H | Recombinant Human LDB3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| LDB3-2154H | Recombinant Human LDB3 Protein (1-283 aa), GST-tagged | E.coli | Human | GST | 1-283 aa |
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| Ldb3-3765M | Recombinant Mouse Ldb3 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| LDB3-5020M | Recombinant Mouse LDB3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| LDB3-5020M-B | Recombinant Mouse LDB3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
LDB3 involved in several pathways and played different roles in them. We selected most pathways LDB3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with LDB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
LDB3 has several biochemical functions, for example, cytoskeletal protein binding,muscle alpha-actinin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LDB3 itself. We selected most functions LDB3 had, and list some proteins which have the same functions with LDB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | TAB3,MARCH9,RAD18,WBP4,CA7,HLTF,UNKL,DTNB,RORAA,PEG10 |
| muscle alpha-actinin binding | PALLD,PDLIM2,NRAP,TTN,PKD2,MYPN,PKD2L1 |
| cytoskeletal protein binding | FRMD5,ALDOC,PTPN4B,NF2A,CAPN2,PDLIM3,PACSIN3,TNNT2A,EPB41L4A,FLNC |
| protein binding | TRIM72,VANGL1,RNMT,NEK9,LCE3E,SMNDC1,ATG12,ACTR1B,SLC40A1,XRN1 |
| protein kinase C binding | SQSTM1,DACT2,ADAM9,ADD3,MARCKS,SDPRB,TRPV4,PRKCSH,TWF2,TDG |
Interacting Protein
LDB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LDB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of LDB3.
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