LDB2
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Official Full Name
LIM domain binding 2 -
Overview
Genes encoding LIM domain-binding factors were initially isolated in a screen for proteins that physically interact;with the LIM domains of nuclear proteins (summarized by Semina et al., 1998 (PubMed 9799849)). These proteins, such as;the one encoded by the LDB2 gene, are capable of binding to a variety of transcription factors and are likely to;function at enhancers to bring together diverse transcription factors and form higher order activation complexes or to;block formation of such complexes (Jurata and Gill, 1997 (PubMed 9315627)). The family of genes encoding LIM;domain-binding factors includes 2 members isolated from the mouse, Clim1 (Bach et al., 1997 (PubMed 9192866)) and;Clim2/Lbd1/Nli (Agulnick et al., 1996 (PubMed 8918878); Jurata et al., 1996 (PubMed 8876198); Bach et al., 1997;(PubMed 9192866)) and their homologs cloned from the frog, chicken, and fly. The fact that LIM domain-binding factors;are likely to be involved in the coordination of the transcriptional activity of many diverse factors might implicate;them in human phenotypes characterized by multiple affected sites. -
Synonyms
LDB2;LIM domain binding 2;LIM domain-binding protein 2;CLIM1;LDB1;LDB-2;CLIM-1;LIM binding domain 2;LIM domain-binding factor-2;LIM domain-binding factor CLIM1;carboxyl-terminal LIM domain-binding protein 1
Recombinant Proteins
- Rhesus macaque
- Chicken
- Mouse
- Human
- Mammalian Cell
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LDB2-2485R | Recombinant Rhesus monkey LDB2 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| LDB2-6392C | Recombinant Chicken LDB2 | Mammalian Cell | Chicken | His |
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| LDB2-9018M | Recombinant Mouse LDB2 Protein | Mammalian Cell | Mouse | His |
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| LDB2-4791HCL | Recombinant Human LDB2 293 Cell Lysate | HEK293 | Human | Non |
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| LDB2-2306R | Recombinant Rhesus Macaque LDB2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| LDB2-2306R-B | Recombinant Rhesus Macaque LDB2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| LDB2-428H | Recombinant Human LDB2 Protein, His-tagged | E.coli | Human | His |
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| LDB2-5019M | Recombinant Mouse LDB2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| LDB2-5019M-B | Recombinant Mouse LDB2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
LDB2 involved in several pathways and played different roles in them. We selected most pathways LDB2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with LDB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
LDB2 has several biochemical functions, for example, LIM domain binding,enzyme binding,transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LDB2 itself. We selected most functions LDB2 had, and list some proteins which have the same functions with LDB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | HMOX1,SLC18A1,KDM1A,ARRB2,UGT1A6A,PIAS3,HYAL2,YWHAE,P4HB,ATG3 |
| transcription cofactor activity | MED4,ZNF710,MED12,HES6,MSX2,LDB2B,PRKCBP1L,ZFP667,PHF21B,BTG1 |
| LIM domain binding | ACTN2,LDB1A,LDB2B,LDB2A,RPH3AL,CSRP2BP,RIPK2,TLN1,LDB1B,LDB1 |
Interacting Protein
LDB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LDB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LDB2.
RLIM;LMO4;gntV
Resources
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References
- Makarev, E; Gorivodsky, M; et al. Islet1 and Its Co-Factor Ldb1 Are Expressed in Quiescent Cells of Mouse Intestinal Epithelium. PLOS ONE 9:-(2014).
