LDB1
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Official Full Name
LIM domain binding 1 -
Overview
LIM domain-binding protein 1 is a protein that in humans is encoded by the LDB1 gene. -
Synonyms
LDB1;LIM domain binding 1;LIM domain-binding protein 1;carboxy terminal LIM domain protein 2;CLIM2;NLI;Carboxyl Terminal LIM Domain Binding 2;CLIM 2;LIM domain binding factor CLIM2;Nuclear LIM Domain Interactor;xldb1;LDB-1;hLdb1;CLIM-2;OTTHUMP00000020360;nuclear LIM interactor;LIM domain-binding factor-1;LIM domain-binding factor CLIM2;carboxyl-terminal LIM domain-binding protein 2
Recombinant Proteins
- Rhesus macaque
- Chicken
- Mouse
- Human
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- His&T7
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LDB1-2484R | Recombinant Rhesus monkey LDB1 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| LDB1-6627C | Recombinant Chicken LDB1 | Mammalian Cells | Chicken | His |
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| LDB1-9017M | Recombinant Mouse LDB1 Protein | Mammalian Cells | Mouse | His |
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| LDB1-4792HCL | Recombinant Human LDB1 293 Cell Lysate | HEK293 | Human | Non |
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| LDB1-1680H | Recombinant Human LDB1 protein, His & T7-tagged | E.coli | Human | His&T7 | Asp112~Gln411 |
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| LDB1-2305R | Recombinant Rhesus Macaque LDB1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| LDB1-2305R-B | Recombinant Rhesus Macaque LDB1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| LDB1-5018M | Recombinant Mouse LDB1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| LDB1-5018M-B | Recombinant Mouse LDB1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| LDB1-5262H | Recombinant Human LDB1 Protein (Asp112-Gln411), N-His tagged | E.coli | Human | His | Asp112-Gln411 |
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Involved Pathway
LDB1 involved in several pathways and played different roles in them. We selected most pathways LDB1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with LDB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | TLX1,Bcl2a1b,ID2,DDX5,MAF,PER2,IL-8,ASPSCR1,HIST1H3C,IGFBP3 |
Protein Function
LDB1 has several biochemical functions, for example, LIM domain binding,RNA polymerase II activating transcription factor binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LDB1 itself. We selected most functions LDB1 had, and list some proteins which have the same functions with LDB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| LIM domain binding | RIPK2,LDB2B,LDB1A,TLN1,LDB2,CSRP2BP,LDB1B,ACTN2,RPH3AL,LDB2A |
| RNA polymerase II activating transcription factor binding | EOMES,EGR2,JUN,MAD2L2,EP300,NHLH2,TBX3,NFE2L2,CREBBP,SMAD3 |
| protein homodimerization activity | TIMM10,PLDN,PLCB1,TG,ZBTB16,MECOM,AIMP1,XBP1,ADD1,CTBP2A |
| transcription corepressor activity | NR0B1,CRYM,HIF3A,CBFA2T3,PPP1R13L,TRIM28,HOMEZB,HIPK2,ANKRD1,SP100 |
| protein binding | RBBP5,PHIP,ITGB4,FOXL2,PPIE,FAM20A,CDKN1B,UBE2I,PNKP,STT3A |
| enhancer sequence-specific DNA binding | YY1,TWIST1B,TBX19,KLF6A,GATA1,XBP1,GATA2,MYT1,GATA4,SOX9 |
| enzyme binding | TRAF2,KRT79,PHB,CYP3A4,CBS,AKT1,PHKG1,TGFB1,PLAUR,GSTM4 |
| protein self-association | ACHE,CCL5,CBR2,CTSB,EPB49,PTH1R,SLC9A3R1,SYP,NKX3-1,CCDC88C |
| chromatin binding | DNMT1,MTA1,FEZF2,C10orf119,REL,CAPNS2,WDR82,NSBP1,ATXN7,KLF14 |
Interacting Protein
LDB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LDB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LDB1.
LMO2;LMO4;4005;LMX1B;LMO1
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References
- Makarev, E; Gorivodsky, M; et al. Islet1 and Its Co-Factor Ldb1 Are Expressed in Quiescent Cells of Mouse Intestinal Epithelium. PLOS ONE 9:-(2014).
- Tanaka, T; Sewell, H; et al. Single Domain Intracellular Antibodies from Diverse Libraries EMPHASIZING DUAL FUNCTIONS OF LMO2 PROTEIN INTERACTIONS USING A SINGLE VH DOMAIN. JOURNAL OF BIOLOGICAL CHEMISTRY 286:3707-3716(2011).
