LAMB3
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Official Full Name
Laminin, Beta 3 -
Overview
The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. -
Synonyms
LAMB3;laminin, beta 3;LAM5;LAMNB1;FLJ99565;BM600-125KDA;laminin subunit beta-3;nicein-125kDa;kalinin B1 chain;laminin B1k chain;OTTHUMP00000034555;OTTHUMP00000034640;laminin S B3 chain;nicein subunit beta;laminin-5 subunit beta;kalinin subunit beta
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- His
- His&GST
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LAMB3-2679H | Recombinant Human LAMB3 protein, His-tagged | E.coli | Human | His | 828-1172 aa | |
| LAMB3-8936M | Recombinant Mouse LAMB3 Protein | Mammalian Cell | Mouse | His |
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| LAMB3-225H | Recombinant Human LAMB3 Protein, His/GST-tagged | E.coli | Human | His&GST | Gly352~Thr587 |
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| Lamb3-226M | Recombinant Mouse Lamb3 Protein, His-tagged | E.coli | Mouse | His | Glu1009~Lys1148 |
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| Lamb3-230R | Recombinant Rat Lamb3 Protein, His-tagged | E.coli | Rat | His | Cys503~Ser738 |
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| LAMB3-4413H | Recombinant Human LAMB3 Protein (Gly352-Thr587), N-GST tagged | E.coli | Human | GST | Gly352-Thr587 |
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| LAMB3-4982M | Recombinant Mouse LAMB3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| LAMB3-4982M-B | Recombinant Mouse LAMB3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
LAMB3 involved in several pathways and played different roles in them. We selected most pathways LAMB3 participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAMB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ECM-receptor interaction | SDC1,VTN,COL5A2,HMMR,COL27A1B,COL4A4,LAMB4,ITGA2B,LAMA3,VTNA |
| Toxoplasmosis | LAMA5,MYD88,HLA-DQA2,IRAK1,LY96,BCL2,NFKBIA,TGFB1,HLA-DQA1,GNAO1 |
| Focal adhesion | VCLA,ROCK2B,DOCK1,BIRC2,PXN,RAP1AA,THBS1,RHOAB,PPP1R12C,FN1 |
| PIK-Akt signaling pathway | ITGA8,Ifna15,PHLPP2,PPP2R1B,VTN,PRKAA1,GNB3,FGF5,PRKCA,PPP2R2D |
| Amoebiasis | COL5A2,SERPINB2,GNA11,TLR2,IL12B,GNAS,SERPINB10,GNA15,COL27A1,GNA14 |
| Pathways in cancer | WNT5A,EPAS1,TRAF2,PIK3CD,MLH1,RARA,FZD6,PDGFA,HDAC1,CXCL12 |
| Small cell lung cancer | BCL2,ITGA3,LAMB4,IKBKG,RXRA,NOS2,APAF1,ITGA2B,FHIT,LAMB2 |
Protein Function
LAMB3 has several biochemical functions, for example, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LAMB3 itself. We selected most functions LAMB3 had, and list some proteins which have the same functions with LAMB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein complex binding | SHANK1,PLK2,WASF2,LEPRE1,BRK1,FLCN,CRIPT,RELA,PDX1,CCND1 |
Interacting Protein
LAMB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAMB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAMB3.
Ywhae
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References
- Reis, ST; Timoszczuk, LS; et al. The role of micro RNAs let7c, 100 and 218 expression and their target RAS, C-MYC, BUB1, RB, SMARCA5, LAMB3 and Ki-67 in prostate cancer. CLINICS 68:652-657(2013).
- Yuen, WY; Lemmink, HH; et al. Herlitz junctional epidermolysis bullosa: diagnostic features, mutational profile, incidence and population carrier frequency in the Netherlands. BRITISH JOURNAL OF DERMATOLOGY 165:1314-1322(2011).
