LAMB1

  • Official Full Name

    laminin, beta 1

  • Overview

    Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.

  • Synonyms

    LAMB1;laminin, beta 1;CLM, cutis laxa with marfanoid phenotype;laminin subunit beta-1;laminin B1 chain;CLM;MGC142015
Cat.# Product name Source (Host) Species Tag Protein Length Price
LAMB1-2564H Recombinant Human LAMB1 protein, His-tagged E.coli Human His Phe549~His767
LAMB1-2565H Recombinant Human SLAMB1 protein, His-tagged E.coli Human His 1437-1786 aa
Lamb1-177H Recombinant Mouse Lamb1 Protein, His/GST-tagged E.coli Mouse His&GST Gln1053~Lys1258
LAMB1-29912TH Recombinant Human LAMB1, His-tagged E.coli Human His 1388-1786 a.a.
Lamb1-1729R Recombinant Rat Lamb1 Protein, His-tagged E.coli Rat His Phe549-His767
LAMB1-2563H Recombinant Human LAMB1 Protein (1533-1782 aa), His-SUMO-tagged E.coli Human His&SUMO 1533-1782 aa

    Involved Pathway

    LAMB1 involved in several pathways and played different roles in them. We selected most pathways LAMB1 participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAMB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Toxoplasmosis IRAK4,PIK3R5,TNF,GNAO1,CYCS,IRGM,HLA-DQB1,PIK3CG,HSPA1A,BCL2L1
    Amoebiasis PIK3R2,COL5A2,SERPINB6B,CSF2,PTK2,LAMA1,SERPINB3,IL1R2,LAMB2,LAMC3
    Small cell lung cancer PTGS2,MAX,TRAF4,RXRB,LAMB3,FHIT,TRAF3,COL4A1,LAMA1,IKBKB
    ECM-receptor interaction CD44,COL4A5,COL4A4,COL24A1,COL11A1A,VTNA,LAMA5,ITGB1B.2,THBS3,THBS1
    PIK-Akt signaling pathway GNG3,IFNA2,FGF10,F2R,IGF1R,FGF9,ITGB8,HSP90AA1,VEGFB,IFNA5
    Focal adhesion PTK2AB,LAMC2,CAPN2A,SHC2,FLT1,VEGFB,HRASA,PXNA,PPP1CA,ITGB6
    Pathways in cancer FGF19,MAX,GNAI2,GNGT1,BIRC3,FGF11,ITGA2,PTK2,RASSF1,SMAD2

    Protein Function

    LAMB1 has several biochemical functions, for example, enzyme binding,extracellular matrix structural constituent,glycosphingolipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LAMB1 itself. We selected most functions LAMB1 had, and list some proteins which have the same functions with LAMB1. You can find most of the proteins on our site.

    Function Related Protein
    glycosphingolipid binding SELP,Cel,SELL,LYN,Il2,LAMA1,LAMC1
    extracellular matrix structural constituent COL11A1A,PXDN,ACAN,BGN,COL5A2,COL27A1B,TINAGL1,LAMA4,MUC5AC,COL11A1B
    integrin binding PXN,S1PR2,DMP1,GPNMB,EMP2,COL5A1,WISP2,SRC,ITGB1,COL4A3
    enzyme binding AXIN2,HIST1H2AG,GSTM7,LGALS9,NOXA1,H2AFX,SELS,CYB5A,AKIRIN2,KMT2E
    structural molecule activity EIF3A,CLDNA,SEMG1,KRT80,KRT26,CLDN12,TUBA1A,CLDN10A,DSP,CRYBB2

    Interacting Protein

    LAMB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAMB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAMB1.

    PDIA3;KARS;CACNA1A;Ogg1;ATXN7;TGFB1;p29991-pro_0000037940;ATXN7L2;GFI1B;FGFR1OP;KIF11;PYHIN1;ESR2;SEPT12

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