L3MBTL1
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Official Full Name
l(3)mbt-like 1 (Drosophila) -
Overview
This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
L3MBTL1;l(3)mbt-like 1 (Drosophila);l(3)mbt (Drosophila) like , l(3)mbt like (Drosophila) , L3MBTL;lethal(3)malignant brain tumor-like protein 1;dJ138B7.3;DKFZp586P1522;KIAA0681;lethal (3) malignant brain tumor l(3);RGD1307316;H-L(3)MBT;H-l(3)mbt protein;L(3)mbt protein homolog;L(3)mbt-like;L3MBT;LMBL1_HUMAN;L3MBTL
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cell
- HEK293T
- HEK293
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
L3MBTL1 involved in several pathways and played different roles in them. We selected most pathways L3MBTL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with L3MBTL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
L3MBTL1 has several biochemical functions, for example, SAM domain binding,chromatin binding,histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by L3MBTL1 itself. We selected most functions L3MBTL1 had, and list some proteins which have the same functions with L3MBTL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| methylated histone binding | WDR92,CDYL2,CBX4,CHD8,ING4,UHRF1,L3MBTL2,TDRD3,RRP8,SPIN1 |
| protein binding | STARD10,RPL14,AF251705,ORC3L,CTH,BEX5,NAA50,SKI,TEX11,COMMD6 |
| chromatin binding | CEBPB,AIRE,RAD51,MEIS3,COQ7,NFATC3,SOX9,RCC1,SP3,BEND6 |
| zinc ion binding | RNF181,ENPEP,SNAI1A,ALPI,DDX58,TNP2,EDEM3,GATAD1,RUNX1,DNAJC24 |
| identical protein binding | TFRC,RIPK1,CCDC155,DAPK3,PHC2,MCM10,BIRC5,MDM2,DRG1,MPST |
| histone binding | RNF20,DAXX,RCC1,HIST1H4F,SUPT6H,UHRF2,HIST1H3I,HIST2H3C,H3F3A,HAT1 |
| transcription factor activity, sequence-specific DNA binding | ZNF8,TADA3,PAX6,ATF4B2,IRF4,ASCL1B,RUNX3,SOX13,SIM1B,SPI1B |
| nucleosomal histone binding | UHRF1,VRK1 |
| nucleosome binding | SMARCA5,MUM1,ZNHIT1,HP1BP3,RNF168,RNF4,RNF169,DNTTIP1,NOC2L,ARID1A |
Interacting Protein
L3MBTL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with L3MBTL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of L3MBTL1.
HIST2H4B;HIST1H1E;HIST1H3D;RB1;CBX3
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References
- Carlson, SM; Moore, KE; et al. Proteome-wide enrichment of proteins modified by lysine methylation. NATURE PROTOCOLS 9:37-50(2014).
- Edwards, CR; Dang, WW; et al. Histone H4 Lysine 20 of Saccharomyces cerevisiae Is Monomethylated and Functions in Subtelomeric Silencing. BIOCHEMISTRY 50:10473-10483(2011).
