KRT86
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Official Full Name
Keratin 86 -
Overview
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix. -
Synonyms
KRT86;keratin 86;hHb6;Basic Hair Keratin K86;HB6;Hb-6;Hb1;MNX;KRTHB1;KRTHB6;keratin, type II cuticular Hb6;K86;keratin-86;hair keratin K2.11;type-II keratin Kb26;keratin, hair, basic, 6;hard keratin, type II, 6;type II hair keratin Hb6;keratin, hair, basic, 6 (monilethrix).
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KRT86-64H | Recombinant Human KRT86 protein, His-tagged | E.coli | Human | His | 501aa(including fusion tag) |
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| KRT86-4861HCL | Recombinant Human KRT86 293 Cell Lysate | HEK293 | Human | Non |
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Involved Pathway
KRT86 involved in several pathways and played different roles in them. We selected most pathways KRT86 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KRT86 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
KRT86 has several biochemical functions, for example, protein binding,structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KRT86 itself. We selected most functions KRT86 had, and list some proteins which have the same functions with KRT86. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | STK3,MBIP,HOXA3,BLOC1S5,STXBP4,MYO18A,PTGDR,FBXW11,CLDN18,POGZ |
| structural molecule activity | KRT12,MTAP7D3,SEMG2,CLDN4,LMNB2,LCE3E,KRT25,CLDN11B,BGLAP,KRT8 |
Interacting Protein
KRT86 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRT86 here. Most of them are supplied by our site. Hope this information will be useful for your research of KRT86.
MEOX2;KRT15;ESR2
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References
- Han, SJ; Rathinaraj, P; et al. Specific Intracellular Uptake of Herceptin-Conjugated CdSe/ZnS Quantum Dots into Breast Cancer Cells. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Torchia, EC; Zhang, L; et al. Aurora Kinase-A Deficiency during Skin Development Impairs Cell Division and Stratification. JOURNAL OF INVESTIGATIVE DERMATOLOGY 133:78-86(2013).
