KLHL20
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Official Full Name
kelch-like 20 (Drosophila) -
Overview
The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities. -
Synonyms
KLHL20;kelch-like 20 (Drosophila);kelch-like protein 20;KHLHX;KLEIP;Kelch like ECT2 interacting protein;Kelch like protein 20;Kelch like protein X;Kelch motif containing protein;Kelch-like ECT2-interacting protein;Kelch-like protein X;KLH20_HUMAN;KLHLX;RP3-383J4.3;kelch-like ECT2 interacting protein
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KLHL20-417H | Recombinant Human KLHL20, His-tagged | E.coli | Human | His | 261-609aa | |
| KLHL20-12245Z | Recombinant Zebrafish KLHL20 | Mammalian Cells | Zebrafish | His |
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| KLHL20-2983C | Recombinant Chicken KLHL20 | Mammalian Cells | Chicken | His |
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| KLHL20-3280R | Recombinant Rat KLHL20 Protein | Mammalian Cells | Rat | His |
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| KLHL20-8711M | Recombinant Mouse KLHL20 Protein | Mammalian Cells | Mouse | His |
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| KLHL20-943HCL | Recombinant Human KLHL20 cell lysate | Human | Non |
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| KLHL20-2936R | Recombinant Rat KLHL20 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| KLHL20-2936R-B | Recombinant Rat KLHL20 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| KLHL20-418H | Recombinant Human KLHL20 protein, His-tagged | E.coli | Human | His | 191-340 aa |
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| KLHL20-4855M | Recombinant Mouse KLHL20 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| KLHL20-4855M-B | Recombinant Mouse KLHL20 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
KLHL20 involved in several pathways and played different roles in them. We selected most pathways KLHL20 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLHL20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| presentation | RNF123,ASB4,ASB7,SEC23A,RNF19B,UBE2U,ASB2,UBE2J2,UBR1,FBXO17 |
| Immune System | AP1B1,WIPF3,USP18,MGC174155,SIGLEC9,BTR12,KLRF1,DEFB4B,UBE2J2,SIGIRR |
| Class I MHC mediated antigen processing & | UBA5,TRIM11,ASB4,MKRN1,CTSL1,PJA2,ASB7,UBE2J2,ASB8,NPEPPS |
| E-cadherin signaling in the nascent adherens junction | WASF2,CTNND1,ABI1,NCKAP1 |
| Proteasome degradation | FBXO27,RNF220,TPP2,FBXO44,UBE2E3,TRIM69,SH3RF1,RNF14,BLMH,SPSB1 |
| Antigen processing: Ubiquitination & | GAN,KLHL21,PJA1,TRIM63,UBE2F,RNF25,ASB7,ASB9,CMTM2A,UFL1 |
| Adaptive Immune System | DNM1,MKRN1,LAIR1,AP2A2,DYNC1I1,FGF20A,CD300LF,CXADR,MGC174857,ASB2 |
Protein Function
KLHL20 has several biochemical functions, for example, actin binding,interferon-gamma binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLHL20 itself. We selected most functions KLHL20 had, and list some proteins which have the same functions with KLHL20. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ubiquitin-protein transferase activity | KLHL7,RBX1,KLHL40A,RNF40,KBTBD6,KBTBD2,BTRC,KLHL21,TCEB1,KBTBD8 |
| protein binding | CCND3,FAH,HIP1R,IL1R2,SPP1,HAND2,DEFA6,MAGEB6,GDF7,SLC4A1AP |
| ubiquitin-protein transferase activity | MIB1,LRSAM1,PDZRN3B,UBE2A,HECW2,LTN1,ARIH1,BRCA1,MUL1,LNX1 |
| actin binding | NRAP,SMTNL,MYLK,MYO5B,MYO1G,PACRG,LCP1,SHROOM2,HIP1,DBNL |
Interacting Protein
KLHL20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLHL20 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLHL20.
PML;DAPK1
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References
- Kather, JN; Friedrich, J; et al. Angiopoietin-1 Is Regulated by miR-204 and Contributes to Corneal Neovascularization in KLEIP-Deficient Mice. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55:4295-4303(2014).
