KLHDC3
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Official Full Name
kelch domain containing 3 -
Overview
The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2 (RAG2), a protein involved in the activation of the V(D)J recombination. In mouse, this gene is found to express specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasma and meiotic chromatin, which suggests that this gene may be involved in meiotic recombination. Alternatively spliced transcript variants have been found. -
Synonyms
KLHDC3;kelch domain containing 3;kelch domain-containing protein 3;dJ20C7.3;hPeas;PEAS;KLDC3_HUMAN;Protein Peas;RP1-20C7.3;Testis intracellular mediator protein
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Insect Cells
- His&Myc
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KLHDC3-405H | Recombinant Human KLHDC3 Protein, His&Myc-tagged | E.coli | Human | His&Myc | 1-382aa | |
| KLHDC3-12462Z | Recombinant Zebrafish KLHDC3 | Mammalian Cells | Zebrafish | His |
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| KLHDC3-3275R | Recombinant Rat KLHDC3 Protein | Mammalian Cells | Rat | His |
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| KLHDC3-8693M | Recombinant Mouse KLHDC3 Protein | Mammalian Cells | Mouse | His |
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| KLHDC3-4921HCL | Recombinant Human KLHDC3 293 Cell Lysate | HEK293 | Human | Non |
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| KLHDC3-2336H | Recombinant Human KLHDC3 protein, His&Myc-tagged | Insect Cells | Human | His&Myc | 1-382aa |
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| KLHDC3-2931R | Recombinant Rat KLHDC3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| KLHDC3-2931R-B | Recombinant Rat KLHDC3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Klhdc3-3705M | Recombinant Mouse Klhdc3 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| KLHDC3-4845M | Recombinant Mouse KLHDC3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| KLHDC3-4845M-B | Recombinant Mouse KLHDC3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
KLHDC3 involved in several pathways and played different roles in them. We selected most pathways KLHDC3 participated on our site, such as IRE1alpha activates chaperones,Metabolism of proteins,Unfolded Protein Response (UPR), which may be useful for your reference. Also, other proteins which involved in the same pathway with KLHDC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Unfolded Protein Response (UPR) | C19orf10,WIPI1,DNAJB9,FKBP14,SERP1,TPP1,YIF1A,SEC63,HYOU1,CTDSP2 |
| Metabolism of proteins | SPCS3,PPP6C,KCNA3,SLC30A8,ACE,PFDN1,PDIA6,MUC13,TIMM17A,BCS1L |
| XBP1(S) activates chaperone genes | C19orf10,HYOU1,YIF1A,HDGF,PDIA6,FKBP14,WIPI1,TPP1,CXXC1,KDELR3 |
| IRE1alpha activates chaperones | CXXC1,CTDSP2,PDIA6,HYOU1,C19orf10,ADD1,SEC63,ASNA1,DDX11,TPP1 |
Protein Function
KLHDC3 has several biochemical functions, for example, chromatin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLHDC3 itself. We selected most functions KLHDC3 had, and list some proteins which have the same functions with KLHDC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | STAT5B,RAG2,NFATC2,FOXC1A,PAX3,CIC,CITED1,WDHD1,TADA2B,SLC30A9 |
| protein binding | TRIM22,CHMP6,TRPM6,STX4A,KDM6B,DTX2,FHOD1,PRKRIP1,POLR2E,PCTP |
Interacting Protein
KLHDC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLHDC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLHDC3.
DLG3;UBXN7;CSNK1E
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References
- Elf, K; Sheuchenko, G; et al. Alterations in muscle proteome of patients diagnosed with amyotrophic lateral sclerosis. JOURNAL OF PROTEOMICS 108:55-64(2014).
- Wang, Q; Burles, K; et al. Ectromelia Virus Encodes a BTB/kelch Protein, EVM150, That Inhibits NF-kappa B Signaling. JOURNAL OF VIROLOGY 88:4853-4865(2014).
- Ikonomov, OC; Sbrissa, D; et al. Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40. JOURNAL OF BIOLOGICAL CHEMISTRY 278:50863-50871(2003).
