KLF5
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Official Full Name
Kruppel-like factor 5 (intestinal) -
Overview
This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] -
Synonyms
KLF5;Kruppel-like factor 5 (intestinal);CKLF;IKLF;BTEB2;Krueppel-like factor 5;BTE-binding protein 2;GC box binding protein 2;colon kruppel-like factor;colon krueppel-like factor;transcription factor BTEB2;intestinal-enriched kruppel-like factor;intestinal-enriched krueppel-like factor;basic transcription element binding protein 2
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- His&T7
- Non
- Avi&Fc&His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KLF5-134H | Recombinant Human KLF5 protein, His-tagged | E.coli | Human | His | Asp216~Asn457 | |
| KLF5-133H | Recombinant Human KLF5 protein, T7/His-tagged | E.coli | Human | His&T7 |
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| KLF5-8685M | Recombinant Mouse KLF5 Protein | Mammalian Cells | Mouse | His |
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| KLF5-3002H | Recombinant Human KLF5 Protein (Leu85-Ala177), N-His tagged | E.coli | Human | His | Leu85-Ala177 |
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| KLF5-3003H | Recombinant Human KLF5 Protein | E.coli | Human | Non |
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| KLF5-4840M | Recombinant Mouse KLF5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| KLF5-4840M-B | Recombinant Mouse KLF5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
KLF5 involved in several pathways and played different roles in them. We selected most pathways KLF5 participated on our site, such as Adipogenesis,Mus musculus biological processes,PluriNetWork, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PluriNetWork | SMARCC1,ZFP143,ZFP57,IPO7,RCOR2,ZMYM2,SALL3,ZSCAN10,XPO4 |
| Mus musculus biological processes | MED11,SUN2,SYCE2,POT1A,SYNE2,SYCP1 |
| Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes | MED11 |
| Adipogenesis | GDF10,DLK1,CEBPA,STIL,NR1H3,RORAA,RETN,HMGA1-RS1,CREB1,EGR2B |
Protein Function
KLF5 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF5 itself. We selected most functions KLF5 had, and list some proteins which have the same functions with KLF5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | HSF1,CHD7,SNAI3,YBX1,SKIL,MYBL1,RFX1A,FOXK2,MSX2,PITX2 |
| transcription factor activity, sequence-specific DNA binding | MYT1,HOXC4,E2F8,ZEB1,PRDM1,TADA2B,ZNF83,TAF13,CEBPA,FOXH1 |
| protein binding | ICAM1,CCDC43,KRTAP4-11,WDFY3,TICAM2,GGA1,LAMA4,SOX4,ATXN3,EPM2A |
| nucleic acid binding | POLR2GL,HELQ,BHLHE22,ZFP92,ARPP21,ZEB2A,ZRANB3,CIZ1,ZBTB41,SP8A |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | CDX4,MEIS3,ELK3,HMGA2,NUCKS1,GATA2,SRF,NR2E1,POU4F3,ONECUT1 |
| sequence-specific DNA binding | SALL1,EMX2,ATF7,ZNF498,VDR,SALL4,MXTX2,NKX2.5,FOXI2,ESRRB |
| DNA binding | NR5A1B,NUSAP1,BCL3,LIN54,EPAS1B,H2AFB1,ETV5A,ZNF496,POLR3F,NEUROD6 |
| metal ion binding | NCS1A,ZNRF2B,ZFP131,ZNF750,CRYABA,ATF2,ASAP2,COLEC12,KMT2A,ACVR1C |
| transcription factor binding | MED1,FHL2,FOXC1,UBN1,HDAC4,FIGLA,HMGB2,NLRP3,MDFI,DOT1L |
Interacting Protein
KLF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF5.
Lyn;Pou5f1;Tfcp2l1;Nanog;Sall4
Resources
Research Area
Transcription Regulators in VSMCTranscription Factors in the Akt Pathway
Embryonic and Induced Pluripotent Stem Cell Markers
Epithelial Cell Markers and Intracellular Molecules
Pluripotent Stem Cell Transcription Factors
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References
- Gyorffy, B; Schafer, R; et al. Biomarkers Downstream of RAS: A Search for Robust Transcriptional Targets. CURRENT CANCER DRUG TARGETS 10:858-868(2010).
- Rageul, J; Mottier, S; et al. KLF4-dependent, PPAR gamma-induced expression of GPA33 in colon cancer cell lines. INTERNATIONAL JOURNAL OF CANCER 125:2802-2809(2009).
