KLF2
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Official Full Name
Kruppel-like factor 2 (lung) -
Overview
Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell;trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L;(SELL; MIM 153240) (summary by Weinreich et al., 2009 (PubMed 19592277)). -
Synonyms
KLF2;Kruppel-like factor 2 (lung);Krueppel-like factor 2;LKLF;KLF 2;KLF2_HUMAN;Kruppel like factor 2;Kruppel like factor;Kruppel like factor LKLF;Lung krueppel like factor;Lung krueppel-like factor;Lung Kruppel like zinc finger transcription factor;Kruppel-like factor LKLF;lung Kruppel-like zinc finger transcription factor
Recombinant Proteins
- Human
- Rat
- Mouse
- HEK293
- Mammalian Cell
- HEK293T
- Mamanlian cells
- Myc&DDK
- His
- Non
- His&Fc&Avi
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KLF2-185H | Recombinant Human KLF2 protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| KLF2-3271R | Recombinant Rat KLF2 Protein | Mammalian Cell | Rat | His |
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| KLF2-4928H | Recombinant Human KLF2 protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| KLF2-4928HCL | Recombinant Human KLF2 293 Cell Lysate | HEK293 | Human | Non |
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| Klf2-1275M | Recombinant Mouse Klf2 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| KLF2-2927R | Recombinant Rat KLF2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| KLF2-2927R-B | Recombinant Rat KLF2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| KLF2-7418HFL | Recombinant Full Length Human KLF2 protein, Flag-tagged | Mamanlian cells | Human | Flag | Full L. |
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Involved Pathway
KLF2 involved in several pathways and played different roles in them. We selected most pathways KLF2 participated on our site, such as FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | PRKAG3B,MAPK8B,MAP2K2,PTEN,GADD45G,INSRA,MAPK14B,HOMER3,TGFB2,CDKN2B |
Protein Function
KLF2 has several biochemical functions, for example, metal ion binding,protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF2 itself. We selected most functions KLF2 had, and list some proteins which have the same functions with KLF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZNF232,EEF2,CDK16,RPS19BP1,UBXN6,CALCOCO2,SCP2,RAD51C,DPH3,TTC19 |
| metal ion binding | BTR22,ZC3H10,ZNF213,RNF169,ZNF518A,LYAR,LEPREL1,TREX1,TDP2B,MAP2K5 |
| transcription factor activity, sequence-specific DNA binding | ZNF394,KCNA3,RXRGA,XBP1,CEBPD,ESRRGA,ZNF167,TAF13,ZIM3,ZSCAN4 |
| sequence-specific DNA binding | SHOX,OTX1A,MKX,NFE2L1A,PKNOX1.1,MYBBP1A,HOXC9,HOXB1B,DLX4A,NKX6.2 |
Interacting Protein
KLF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF2.
SMURF1;SMURF1
Resources
Research Area
Transcription Regulators in Endothelial CellsTranscription Regulators in VSMC
Intracellular Signaling Molecules in Angiogenesis
Pluripotent Stem Cell Transcription Factors
Related Services
Related Products
References
- Ware, CB; Nelson, AM; et al. Derivation of naive human embryonic stem cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:4484-4489(2014).
- Allen, KL; Jain, MK; et al. KLF2 and KLF4 Are Essential Mediators of the Anti-Thrombotic Effects of Statins in the Presence of Antiphospholipid/Anti-beta(2)GPI Antibodies. BLOOD 118:1407-1407(2011).
