KLF12
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Official Full Name
Kruppel-like factor 12 -
Overview
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
KLF12;Kruppel-like factor 12;Krueppel-like factor 12;AP 2 repressor;AP 2rep;AP 2rep transcription factor;AP2REP;HSPC122;KLF12 zinc finger transcriptional repressor;AI315654;AP-2rep;B130052C06Rik;D530033K05Rik;OTTHUMP00000018503;2700063E05Rik;AI225908;AP-2 repressor;AP-2rep transcription factor;Krueppel like factor 12;Transcriptional repressor AP 2rep;transcriptional repressor AP-2rep
Recombinant Proteins
- Rhesus macaque
- Human
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- His
- His&Fc&Avi
Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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KLF12-2413R | Recombinant Rhesus monkey KLF12 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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KLF12-602H | Recombinant Human Kruppel-like factor 12, His-tagged | E.coli | Human | His | 1-402 a.a. |
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KLF12-8676M | Recombinant Mouse KLF12 Protein | Mammalian Cells | Mouse | His |
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KLF12-2234R | Recombinant Rhesus Macaque KLF12 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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KLF12-2234R-B | Recombinant Rhesus Macaque KLF12 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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KLF12-4835M | Recombinant Mouse KLF12 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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KLF12-4835M-B | Recombinant Mouse KLF12 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
KLF12 involved in several pathways and played different roles in them. We selected most pathways KLF12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Protein Function
KLF12 has several biochemical functions, for example, DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF12 itself. We selected most functions KLF12 had, and list some proteins which have the same functions with KLF12. You can find most of the proteins on our site.
Function | Related Protein |
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transcription corepressor activity | PBXIP1,DRAP1,RCOR2,TMEM38A,NR0B1,NCOR2,SKOR1A,HOMEZA,ZMYND11,PPP1R13L |
DNA binding | POLG,VEZF1,XRCC5,ZNF473,DHX36,FLYWCH1,RARAA,RAD50,UNCX,MCMDC2 |
transcription factor activity, sequence-specific DNA binding | PBX4,ZC3H8,HOXC8,ZSCAN4C,HSF2,CLOCKB,NR3C1,EGR2A,HCFC1,MYT1LA |
metal ion binding | ZNF707,GNAI1,CAR7,BMPR1BA,ZNFX1,SCAPER,HELZ2,ZKSCAN14,SIAH2L,ZNF19 |
protein binding | POGZ,JAKMIP1,ABCB1,MYLK,SCO2,MICAL1,TCERG1,NUDCD3,EXOC3-AS1,RIPPLY1 |
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | ARID5B,ISX,E2F7,ZC3H8,E4F1,NFKB1,MSX2,ESX1,VAX1,CDX2 |
RNA polymerase II regulatory region sequence-specific DNA binding | RXRG,ZFP551,H2AFY,CGGBP1,EOMES,PURB,ZNF256,NR1D1,SP3,GATA2B |
Interacting Protein
KLF12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF12 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF12.
CTBP1;THAP1;EHMT2
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References
- Pentheroudakis, G; Kotoula, V; et al. A study of gene expression markers for predictive significance for bevacizumab benefit in patients with metastatic colon cancer: a translational research study of the Hellenic Cooperative Oncology Group (HeCOG). BMC CANCER 14:-(2014).