KLC3

  • Official Full Name

    kinesin light chain 3

  • Overview

    This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria.

  • Synonyms

    KLC3;kinesin light chain 3;KLC2L;KLCt;KNS2B;Kinesin light chain 2;KLC2;KLC2 like;KLC2-like;KLC3_HUMAN

Recombinant Proteins

  • Rat
  • Zebrafish
  • Mouse
  • Human
  • Mammalian Cell
  • E.coli
  • Yeast
  • HEK293
  • HEK293T
  • His
  • Non
  • His&SUMO
  • His&Fc&Avi
  • GST
  • Myc&DDK

    Involved Pathway

    KLC3 involved in several pathways and played different roles in them. We selected most pathways KLC3 participated on our site, such as Adaptive Immune System,Factors involved in megakaryocyte development and platelet production,Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RHO GTPase Effectors CIT,ABI1A,ERCC6L,NOXA1,RHOGA,SPDL1,ABI2,NOXO1A,RHOC,PMF1
    Adaptive Immune System TRIM9,MGC174155,CTSH,CD207,TRIM50,UBE2V2,AGO2,FGF20A,RNF25,DNM1
    RHO GTPases activate KTN1 KTN1
    Kinesins KIF26A,KIFC1,KIF3C,KIF22,KIF9,KIFAP3,KIF3B,RACGAP1,KIF2A,KIF2B
    Immune System CLEC2D,RAP1GAP2B,NLRP4,TXNIPB,IFITM2,RAPGEF3,CD200,TRIM14,CRCP,CASP4
    MHC class II antigen presentation ACTR1B,CTSE,CTS7,FAM49BA,KIFAP3,KIF3B,MGC174155,KIF15,CTSH,MGC174857
    Hemostasis MERTK,DOCK9,KIF26A,S100A10B,KIF20A,VPS45,AKAP1,MAFG,CLEC1B,TRPC7
    Factors involved in megakaryocyte development and platelet production KIF20A,CABLES2,GATA2,RACGAP1,DOCK8,GATA6,MAFF,KIFC1,KIF2C,KIF22

    Protein Function

    KLC3 has several biochemical functions, for example, kinesin binding,microtubule binding,microtubule motor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLC3 itself. We selected most functions KLC3 had, and list some proteins which have the same functions with KLC3. You can find most of the proteins on our site.

    Function Related Protein
    microtubule motor activity KIF5B,DNHD1,KIF1B,KIF3B,KIF11,KIF7,DNAH6,DNAH5,DNAH9,KIF26A
    protein binding EFCAB4A,CAMK2A,KCTD17,ALDOB,RBM11,MAP1S,LRRC26,HTR1B,SIRT4,TMEM115
    kinesin binding GOLSYN,KTN1,PPIAL4A,DISC1,SNCA,AP1AR,ARHGEF10,KCNC1,PLEKHM2,NEFH
    microtubule binding FNTA,SPAST,ZNF207,DPYSL2,JAKMIP1,CRYAB,KIF12,KIF21A,NME8,UXT

    Interacting Protein

    KLC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLC3.

    KRT13;CCDC64B;147700;NECAB2;NDC80;STX11;TCF4

    Resources

    References

    • Bhullar, B; Zhang, Y; et al. Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion. JOURNAL OF BIOLOGICAL CHEMISTRY 278:16159-16168(2003).

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