KIF5A

  • Official Full Name

    kinesin family member 5A
  • Overview

    This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10.
  • Synonyms

    KIF5A;kinesin family member 5A;spastic paraplegia 10 (autosomal dominant) , SPG10;kinesin heavy chain isoform 5A;D12S1889;MY050;NKHC;KIF5A variant protein;neuronal kinesin heavy chain;kinesin heavy chain neuron-specific 1;kinesin, heavy chain, n

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
KIF5A-376H Recombinant Human KIF5A, GST-tagged E.coli Human GST C-102aa
KIF5A-259H Recombinant Human KIF5A Protein, His-tagged E.coli Human His Leu473~Cys605
Kif5a-260M Recombinant Mouse Kif5a Protein, His/GST-tagged E.coli Mouse GST&His Ala2~Ile211
Kif5a-261R Recombinant Rat Kif5a Protein, His/GST-tagged E.coli Rat GST&His Ile823~Ser1027
KIF5A-3258R Recombinant Rat KIF5A Protein Mammalian Cells Rat His
KIF5A-8647M Recombinant Mouse KIF5A Protein Mammalian Cells Mouse His
KIF5A-2361H Recombinant Human KIF5A Protein, His-tagged E.coli Human His Val174-Lys315
KIF5A-2914R Recombinant Rat KIF5A Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
KIF5A-2914R-B Recombinant Rat KIF5A Protein Pre-coupled Magnetic Beads HEK293 Rat
KIF5A-4819M Recombinant Mouse KIF5A Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
KIF5A-4819M-B Recombinant Mouse KIF5A Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    KIF5A involved in several pathways and played different roles in them. We selected most pathways KIF5A participated on our site, such as Adaptive Immune System,Dopaminergic synapse,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIF5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Kinesins KIF4A,KIF20A,KIF18A,KIF3C,KIF15,CENPE,KIF4,KIF2B,KIF3B,KIF11
    Immune System OSBPL1A,UBR2,CXADR,ASB18,CD200R1,RNF14,KIF5B,CD160,KIF18A,IFIT11
    Factors involved in megakaryocyte development and platelet production LRRC16A,DOCK8,HBB-Y,HBBE3,KIF26A,PHF21A,KIFC1,IRF2,HBG2,ZFPM1
    Endocytosis STAMBPA,ASAP1A,RAB35B,FOLR2,ACAP3,CBL,EPN2,EHD4,EPS15,CHMP3
    Adaptive Immune System BTLA,MAPKAP1,MICA,RNF182,CTS7,ACTR1A,ASB10,NCR3LG1,HUWE1,KIF2A
    Hemostasis MGC173646,BRPF3,GNA13,CABLES1,APOER2,KIF2A,VPS45,TAE1,PRKCHB,RHOB
    Dopaminergic synapse CREB3L4,DRD5,PPP2CB,DRD4,DRD3,PPP2R5C,CAMK2A,AKT1,ITPR1,GNG7
    Insulin processing CPE,KIF5B,EXOC5,EXOC8,PCSK1,CPN1,EXOC3,SLC30A5,SLC30A8,RAB27A

    Protein Function

    KIF5A has several biochemical functions, for example, ATP binding,ATP-dependent microtubule motor activity, plus-end-directed,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KIF5A itself. We selected most functions KIF5A had, and list some proteins which have the same functions with KIF5A. You can find most of the proteins on our site.

    Function Related Protein
    motor activity CGNB,SMYHC2,MYH9,MYO5A,DNAL4,DYNC2LI1,MYH4,DYNLT1,DCTN2,MYO7AA
    ATP-dependent microtubule motor activity, plus-end-directed KIF1B,KIF11,KIF19,KIF3B,KIF1C,KIF5AA,KIF14,KIF3A,KIF5C,KIF18B
    microtubule binding HAUS8,CHD4,KIF16B,GABARAPA,EZR,AKAP1,RAB11A,NUSAP1,MAST2,GABARAPL1
    protein binding IL2RB,PIAS3,RUFY1,MSH6,QRICH1,C7orf25,PPFIA4,POLR2E,LRIF1,RELA
    ATP binding STK32C,RAD54L,CDK11B,FAM20C,ULK2,KIF5B,ACVR1BA,ACTA1B,PLK5,PRKACAB

    Interacting Protein

    KIF5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIF5A here. Most of them are supplied by our site. Hope this information will be useful for your research of KIF5A.

    ANKRD27;RXRB;PCBD1;MDM2;Trak2;TRAK1;MAP4K4;TK1;Hap1;PIN1;TP53BP2;ITSN1;SMN1;TRAF3IP1;M

    Resources

    References

    • Uchida, A; Alami, NH; et al. Tight Functional Coupling of Kinesin-1A and Dynein Motors in the Bidirectional Transport of Neurofilaments. MOLECULAR BIOLOGY OF THE CELL 20:4997-5006(2009).
    • van der Linden, MPM; Feitsma, AL; et al. Association of a Single-Nucleotide Polymorphism in CD40 With the Rate of Joint Destruction in Rheumatoid Arthritis. ARTHRITIS AND RHEUMATISM 60:2242-2247(2009).

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