KIF4A
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Official Full Name
kinesin family member 4A -
Overview
This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X. -
Synonyms
KIF4A;kinesin family member 4A;chromosome-associated kinesin KIF4A;chromokinesin;FLJ12530;FLJ12655;FLJ14204;FLJ20631;HSA271784;KIF4;KIF4 G1;chromokinesin-A;KIF4G1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KIF4A-375H | Recombinant Human KIF4A, GST-tagged | E.coli | Human | GST | 1-351aa | |
| KIF4A-6534C | Recombinant Chicken KIF4A | Mammalian Cells | Chicken | His |
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| KIF4A-4944HCL | Recombinant Human KIF4A 293 Cell Lysate | HEK293 | Human | Non |
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Involved Pathway
KIF4A involved in several pathways and played different roles in them. We selected most pathways KIF4A participated on our site, such as Adaptive Immune System,Axon guidance,Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIF4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | EFNB2A,NKX2.2A,SCN8A,RASGRP4,SPNA1,SPAG9,RHOC,EPHA2,ARPC3,DPYSL5A |
| Axon guidance | CLASP1,ABLIM2,SPTBN1,NADL1.1,EPHB3A,ARPC5,DPYSL5A,DLG4,CHL1,EPHB1 |
| Adaptive Immune System | TREML4,TREML1,HECTD3,UBE2J2,TRIM9,FGFR1B,ATG7,AKT3,DYNC1H1,CTLA4 |
| L1CAM interactions | SCN3B,SCN9A,RANBP9,DPYSL2B,DPYSL2,EZRA,DLG3,CNTN1,KCNQ2,SCN2A |
| Immune System | NLRC5,RNF144B,PPAPDC1B,LRRC41,KIF11,TXNIPB,DEFB106A,FBXO17,RNF123,PPAPDC1A |
| Hemostasis | ANXA2A,PDPN,JAM2B,SLC7A8A,MMRN1,EHD1,DGKQ,SLC3A2A,MAFGA,DOCK6 |
| Kinesins | KIF4,KIF2B,KIF3B,KIF20A,KIF22,KIFAP3,KIF18A,KIF5A,KLC3,KIF9 |
| Factors involved in megakaryocyte development and platelet production | KIF11,HMG20B,MAFGA,HBD,GATA1A,KIF2A,KIFC1,KIF3A,MAFG,HBBE3 |
Protein Function
KIF4A has several biochemical functions, for example, ATP binding,ATPase activity,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KIF4A itself. We selected most functions KIF4A had, and list some proteins which have the same functions with KIF4A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| microtubule binding | CLASP1,LRPPRC,NDE1,MAPRE2,SBDS,TRIM54,MAP205,KIF11,VAPB,TUBGCP5 |
| protein binding | DDR2,ARIH1,FAM167A,SCAND1,ZNRF1,TNPO1,C17orf82,MAL,PTGES3,SNX8 |
| DNA binding | PHF5A,DMTF1,NPAS4A,HIST1H2BD,ZNF597,FOXO1B,ZBTB9,ZSCAN4D,LCORL,NR1I3 |
| ATP binding | UBE2Z,GTF2F2,TRPM4,ABCA5,HSP104,GK,PARS2,MAP2K1,MYH7,MYO3A |
| ATPase activity | KIF20B,PMS2,DNAH11,INO80,KIF2B,ABCA1B,BLM,PSMD6,CLPX,MLH3 |
| microtubule motor activity | DNAHC8,KIF22,KIF6,KIF2B,KIF23,KIF14,KIF27,DYNC1LI1,DYNC1LI2,KIF2C |
Interacting Protein
KIF4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIF4A here. Most of them are supplied by our site. Hope this information will be useful for your research of KIF4A.
Kif4;DNPEP;SVIL;pi3p;SNW1;CDC5L;TTF2;PRC1
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References
- Fouz, N; Amid, A; et al. Gene Expression Analysis in MCF-7 Breast Cancer Cells Treated with Recombinant Bromelain. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 173:1618-1639(2014).
- Minakawa, Y; Kasamatsu, A; et al. Kinesin Family member 4A: A Potential Predictor for Progression of Human Oral Cancer. PLOS ONE 8:-(2013).
