KIF3B
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Official Full Name
kinesin family member 3B -
Overview
The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. -
Synonyms
KIF3B;kinesin family member 3B;kinesin-like protein KIF3B;KIAA0359;HH0048;KIF3B_HUMAN;Kinesin like protein KIF3B;Microtubule plus end directed kinesin motor 3B;Microtubule plus end-directed kinesin motor 3B;Similar to Mouse kinesin KIF3B;OTTHUMP00000030588
Recombinant Proteins
- Chicken
- Rhesus macaque
- Zebrafish
- Human
- Mouse
- Mammalian Cells
- HEK293
- His
- Non
- DDK
- Myc
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KIF3B-2058C | Recombinant Chicken KIF3B | Mammalian Cells | Chicken | His |
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| KIF3B-2406R | Recombinant Rhesus monkey KIF3B Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| KIF3B-5883Z | Recombinant Zebrafish KIF3B | Mammalian Cells | Zebrafish | His |
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| KIF3B-931HCL | Recombinant Human KIF3B cell lysate | Human | Non |
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| Kif3b-1268M | Recombinant Mouse Kif3b Protein, MYC/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| KIF3B-2227R | Recombinant Rhesus Macaque KIF3B Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| KIF3B-2227R-B | Recombinant Rhesus Macaque KIF3B Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| KIF3B-3962H | Recombinant Human KIF3B Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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Involved Pathway
KIF3B involved in several pathways and played different roles in them. We selected most pathways KIF3B participated on our site, such as Adaptive Immune System,Assembly of the primary cilium,Factors involved in megakaryocyte development and platelet production, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIF3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Factors involved in megakaryocyte development and platelet production | DOCK10,HBD,HBB-Y,KIF22,RACGAP1,GATA2,DOCK11,CBX5,KIF15,MFN2 |
| Adaptive Immune System | TRIM11,KLHL21,RASGRP2,GAN,RNF144B,STIM1B,RNF123,CD300LH,NRG4,DTX3L |
| Immune System | IRAK3,TRIM50,TRIM14,PJA2,DEFA6,CTS7,ADAR,ASB8,AP1S1,KPNA4 |
| Kinesins | KIF2C,KIF5A,KIF20A,KIF22,KIF4,RACGAP1,KIFC1,KLC3,CENPE,KIF2B |
| Hemostasis | CABLES1,KIF11,S100A10A,FN1B,Alb,MMRN1,DOCK9,GNA13B,AKAP1,SLC7A11 |
| Intraflagellar transport | KIFAP3,FLR,TTC30A,TTC26,OST4,IFT122,KIF3C,TTC30B,IFT-20,DYNLL2A |
| Assembly of the primary cilium | TTC30A2,SSTR3,DCTN1,CCT3,CSNK1E,TCP1,CCP110,AKAP9,CETN2,ODF2 |
| MHC class II antigen presentation | KIF15,CTS7,AP1S3A,DYNC1LI2,CTSC,FAM49BA,KLC3,CTSLL,CTSO,RACGAP1 |
Protein Function
KIF3B has several biochemical functions, for example, ATP binding,ATP-dependent microtubule motor activity, plus-end-directed,Rho GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KIF3B itself. We selected most functions KIF3B had, and list some proteins which have the same functions with KIF3B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| microtubule binding | MTAP6,KIF20A,CAMSAP1A,KIF4,KIF17,ZNF207,SERPINB1A,CNN3,KRIT1,PEX14 |
| ATP binding | CDKL3,PRKACAB,MCCC1,CLPX,CDK12,EPHB2,ULK1,DDX3X,TCP1,TWF2 |
| protein binding | SULT1B1,TAL1,UGP2,POLR3F,MMP14,ITGB3BP,COMMD9,TTC19,BANK1,IL32 |
| Rho GTPase binding | DOCK10,PARD6A,PFN1,DOCK9,AKAP13,LRRK2,DIAPH3,DIAP1,ROCK2A,FLNA |
| microtubule motor activity | DYNLRB2,BBS4,KLC3,DYNC1LI1,KLC1,KIF3C,SMC3,DNAIC2,KIF6,KLC1A |
| ATP-dependent microtubule motor activity, plus-end-directed | KIF5B,KIF5AA,KIF18A,KIF5C,KIF3A,KIF19,KIF1C,KIF1B,KIF20B,KIF14 |
Interacting Protein
KIF3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIF3B here. Most of them are supplied by our site. Hope this information will be useful for your research of KIF3B.
KIFAP3;ARHGEF10;LMO2;LMO4;Mphosph9;Hax1;Magoh;Sptlc2;KIF3A;Homer1
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References
- Qiu, DY; Cheng, SM; et al. Localization and loss-of-function implicates ciliary proteins in early, cytoplasmic roles in left-right asymmetry. DEVELOPMENTAL DYNAMICS 234:176-189(2005).
- Baker, SA; Freeman, K; et al. IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia. JOURNAL OF BIOLOGICAL CHEMISTRY 278:34211-34218(2003).
