KIF14
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Official Full Name
kinesin family member 14 -
Overview
KIF14 is a member of the kinesin superfamily of microtubule-associated motors (see MIM 148760) that play important;roles in intracellular transport and cell division (Nakagawa et al., 1997 (PubMed 9275178)). -
Synonyms
KIF14;kinesin family member 14;kinesin-like protein KIF14;KIAA0042;KIF 14;Kinesin like protein KIF14;MGC142302
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KIF14-1051H | Recombinant Human KIF14 | Mammalian Cells | Human | His |
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| KIF14-4064Z | Recombinant Zebrafish KIF14 | Mammalian Cells | Zebrafish | His |
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| KIF14-925HCL | Recombinant Human KIF14 cell lysate | Human | Non |
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| KIF14-2360H | Recombinant Human KIF14 Protein, His-tagged | E.coli | Human | His | Ala1520-Val1648 |
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| KIF14-3212H | Recombinant Human KIF14 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| KIF14-3212H-B | Recombinant Human KIF14 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
KIF14 involved in several pathways and played different roles in them. We selected most pathways KIF14 participated on our site, such as RHO GTPase Effectors,RHO GTPases activate CIT,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIF14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RHO GTPases activate CIT | PRC1B,CIT,RHOAE,PRC1 |
| Signal Transduction | RGS20,ARHGAP40,PLEKHG2,RLN1,RCA2.1,PCSK5,METAP2,HEYL,SOX7,ARHGAP31 |
| Signaling by Rho GTPases | RHPN1,MYO9B,ARHGAP6,ARHGAP44,ARHGAP9,ARHGAP10,RHOJ,RHOV,FGD2,CIT |
| RHO GTPase Effectors | MKL1B,RHPN1,SGOL2,NDEL1A,RANGAP1B,PRC1B,ACTR2B,CCDC99,RHOAE,FMNL2 |
Protein Function
KIF14 has several biochemical functions, for example, ATP binding,ATP-dependent microtubule motor activity, plus-end-directed,ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KIF14 itself. We selected most functions KIF14 had, and list some proteins which have the same functions with KIF14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ENSA,PCGF1,C1orf216,ZCCHC8,FAM167A,ZFYVE21,PRMT3,C2orf28,CLOCKB,HIST1H4H |
| microtubule binding | MACF1,BIRC5,MAPT,HOOK3,VPS41,SPAG8,MAP6D1,BCL2L11,RCC2,KIF16B |
| PDZ domain binding | USHBP1,ERC1,ACOX1,ADRB1,Apba1,SLC22A5,GRIA1,PDZK1,PLEKHA1,ARHGEF16 |
| microtubule motor activity | DYNC1H1,BBS4,KIFC3,KIF15,DNAH6,KIF6,DNAH11,KIFC1,KLC2,KIF23 |
| ATP binding | DYNC1LI2,TTF2,EPHB2,TEP1,ARAF,GLULC,CASKB,DDX3X,HSPA9,SRX1 |
| protein kinase binding | SFN,PTPRC,TRAF2,Fert2,JIP1,TRP53,PDPK1,IL12RB2,PTK2,TRPV4 |
| ATP-dependent microtubule motor activity, plus-end-directed | KIF18A,KIF5AA,KIF18B,KIF1B,KIF16B,KIF5A,KIF3A,KIF5B,KIF3B,KIF1C |
| ATPase activity | ABCE1,HSPA1A,ATP13A,WRNIP1,ABCD3A,ATAD1,Abca2,ATF7IP,ABCB4,ABCD3 |
| tubulin binding | EML1,CLIP1,PARK2,AGTPBP1,TBCC,TTLL6,LRRK2,STMN1B,RABGAP1,STMN1 |
Interacting Protein
KIF14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIF14 here. Most of them are supplied by our site. Hope this information will be useful for your research of KIF14.
SVIL;RIPK2;PSTPIP1;Gorasp1;Cit;URB1;ATP5I;HNRNPA1L2;CCDC14;Kif1bp;Trim32;KIF1BP;TSNAX;TUBA1C;KLC4;Naa10;TJP2;TMCO1
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References
- Theriault, BL; Cybulska, P; et al. The role of KIF14 in patient-derived primary cultures of high-grade serous ovarian cancer cells. JOURNAL OF OVARIAN RESEARCH 7:-(2014).
- Yang, T; Li, XN; et al. Sox17 inhibits hepatocellular carcinoma progression by downregulation of KIF14 expression. TUMOR BIOLOGY 35:11199-11207(2014).
