KERA
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Official Full Name
keratocan -
Overview
The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2). -
Synonyms
KERA;keratocan;CNA2;keratocan proteoglycan;SLRR2B;KERA_HUMAN;Keratan sulfate proteoglycan keratocan;KTN
Recombinant Proteins
- Zebrafish
- Chicken
- Cattle
- Mouse
- Human
- Goat
- Mammalian Cells
- E.coli
- HEK293
- Goat cornea
- His
- His&T7
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KERA-3161Z | Recombinant Zebrafish KERA | Mammalian Cells | Zebrafish | His |
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| KERA-5750C | Recombinant Chicken KERA | Mammalian Cells | Chicken | His |
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| KERA-7879C | Recombinant Cattle KERA protein, His & T7-tagged | E.coli | Cattle | His&T7 | Arg21~Asn292 |
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| Kera-7880M | Recombinant Mouse Kera protein, His & T7-tagged | E.coli | Mouse | His&T7 | Gln21~His292 |
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| KERA-4989HCL | Recombinant Human KERA 293 Cell Lysate | HEK293 | Human | Non |
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| KERA-01G | Active Native Goat KERA protein | Goat cornea | Goat | 352aa |
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| KERA-2359H | Recombinant Human KERA Protein, His-tagged | E.coli | Human | His | His38-Pro335 |
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Involved Pathway
KERA involved in several pathways and played different roles in them. We selected most pathways KERA participated on our site, such as Defective B4GALT1 causes B4GALT1-CDG (CDG-2d),Defective CHST6 causes MCDC1,Defective ST3GAL3 causes MCT12 and EIEE15, which may be useful for your reference. Also, other proteins which involved in the same pathway with KERA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Defective ST3GAL3 causes MCT12 and EIEE15 | FMOD,OGN,ACAN,PRELP |
| Diseases of glycosylation | FMOD,ACAN,PRELP,OGN |
| Diseases associated with glycosaminoglycan metabolism | FMOD,ACAN,OGN,PRELP |
| Disease | CTBP1,CDK9,GYG1,MMAA,CCDC167,OPN1SW,AP2A1,RLBP1,AP1M2,CFTR |
| Keratan sulfate biosynthesis | B3GNT3,ST3GAL3A,OGN,FMODA,PRELP,OMD,B3GNT2A,SLC35D2,B3GNT2,B3GNT1 |
| Glycosaminoglycan metabolism | UST,OGN,BGNA,LYVE1,GPC1A,HPSE,HS3ST6,SLC35B2,B3GNT1,GPC1B |
| Defective CHST6 causes MCDC1 | PRELP,OGN,FMOD,ACAN |
| Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) | OGN,ACAN,PRELP,FMOD |
Protein Function
KERA has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by KERA itself. We selected most functions KERA had, and list some proteins which have the same functions with KERA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | OXNAD1,CD248,TBC1D9,MID1IP1B,ZNF697,DEFB50,WDR53,FAM185A,C1QL3B,HSPA7 |
Interacting Protein
KERA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KERA here. Most of them are supplied by our site. Hope this information will be useful for your research of KERA.
Dlg4;CDC37
Resources
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References
- Conrad, AH; Conrad, GW; et al. The keratocan gene is expressed in both ocular and non-ocular tissues during early chick development. MATRIX BIOLOGY 22:323-337(2003).
