KDM5D
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Official Full Name
lysine (K)-specific demethylase 5D -
Overview
This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient. Alternative splicing results in multiple transcript variants. -
Synonyms
KDM5D;lysine (K)-specific demethylase 5D;HY, HYA, JARID1D, jumonji, AT rich interactive domain 1D , Jumonji, AT rich interactive domain 1D (RBP2 like) , SMCY, Smcy homolog, Y linked (mouse);lysine-specific demethylase 5D;KIAA0234;H-Y;Histocompatibility Y antigen;HY;HYA;JAD1D;Jumonji/ARID domain-containing protein 1D;protein SmcY;Smcy homolog, Y-linked;SMC homolog, Y chromosome;Smcy homolog, Y chromosome;histone demethylase JARID1D;selected mouse cDNA on Y, human homolog of;Jumonji, AT rich interactive domain 1D (RBP2-like);SMCY;JARID1D
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KDM5D-8597M | Recombinant Mouse KDM5D Protein | Mammalian Cells | Mouse | His |
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| KDM5D-4785M | Recombinant Mouse KDM5D Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| KDM5D-4785M-B | Recombinant Mouse KDM5D Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
KDM5D involved in several pathways and played different roles in them. We selected most pathways KDM5D participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM5D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HDMs demethylate histones | KDM7AB,JMJD6,PHF2,ARID5B,PHF8,KDM5B,KDM3B,JHDM1D,KDM4B,KDM4A |
| Chromatin organization | BRMS1,BRD8,VPS72,ATF7IP,KDM1B,SMARCD3B,SAP30,PBRM1L,PHF17,KDM3A |
| Chromatin modifying enzymes | PADI3,PAX3A,ELP4,ING3,ARID1A,KDM5BB,BRPF1,MORF4L1,KDM4D,SMARCA2 |
Protein Function
KDM5D has several biochemical functions, for example, 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity,C-19 gibberellin 2-beta-dioxygenase activity,C-20 gibberellin 2-beta-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM5D itself. We selected most functions KDM5D had, and list some proteins which have the same functions with KDM5D. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| C-19 gibberellin 2-beta-dioxygenase activity | KDM5BB,PHF2,JMJD1C |
| metal ion binding | FGD1,ZNF213,CYP2AA8,TGM2A,GALNT13,ZNF207A,SPNA1,TNNI3K,FBP2,TIMM8B |
| DNA-N1-methyladenine dioxygenase activity | ALKBH3,FTO,KDM5BB,PHF2,JMJD1C,ALKBH2 |
| dioxygenase activity | PHF2,KDM6A,TDO2B,ASPHD1,ADOB,ADOA,OGFOD3,BCO2L,JMJD5,HPDB |
| DNA binding | SCXB,RAD51C,ZFP687,TEAD1,SMC1B,NPAS1,HIST1H2BB,ZBTB20,ZNF496,ZNF556 |
| zinc ion binding | THRB,HE1B,SIRT2,KDM2AA,ZC3HC1,PTGR1,FBXO11,GATAD2A,ZDHHC23,CNOT4 |
| histone demethylase activity (H3-K4 specific) | KDM1A,C14orf169,KDM5C,KDM5B |
| hypophosphite dioxygenase activity | PHF2,KDM5BB,JMJD1C |
| sulfonate dioxygenase activity | JMJD1C,KDM5BB,PHF2 |
Interacting Protein
KDM5D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM5D here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM5D.
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References
- Kawase, T; Ord, ND; et al. Frequency and Intensity of Antibody Responses to Antigens Encoded by KDM5D (SMCY) and Other H-Y Genes After Allogeneic Hematopoietic Cell Transplantation. BLOOD 118:1721-1721(2011).
