KDM4D

  • Official Full Name

    lysine (K)-specific demethylase 4D

  • Overview

    Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

  • Synonyms

    KDM4D;lysine (K)-specific demethylase 4D;JMJD2D;lysine-specific demethylase 4D;jumonji domain containing 2D;jumonji domain-containing protein 2D;jmjC domain-containing histone demethylation protein 3D

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • Sf9 Cells
  • Mammalian Cells
  • HEK293
  • E.coli
  • Flag
  • His
  • Non
  • StrepII
  • His&Fc&Avi

    Involved Pathway

    KDM4D involved in several pathways and played different roles in them. We selected most pathways KDM4D participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM4D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chromatin modifying enzymes PRDM16,SETD3,WDR77,PRMT6,KIAA1267,CAPNS2,CSRP2BP,NCOA2,SMARCE1,TADA3
    Chromatin organization KAT6B,PADI4,KANSL2,TADA2A,KAT7B,SMARCC2,RBBP5,SMARCB1A,C3orf75,JMJD6
    HDMs demethylate histones KDM2B,KDM6B,PHF8,JMJD6,PHF2,KDM4C,JHDM1D,KDM3A,KDM3B,KDM5BB

    Protein Function

    KDM4D has several biochemical functions, for example, dioxygenase activity,histone demethylase activity (H3-K9 specific),metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM4D itself. We selected most functions KDM4D had, and list some proteins which have the same functions with KDM4D. You can find most of the proteins on our site.

    Function Related Protein
    histone demethylase activity (H3-K9 specific) KDM4C,KDM7AB,KDM1A,PHF2,JHDM1D,PHF8
    metal ion binding TIMP1,CYP8B1,ZSCAN18,ZNF544,GFI1AA,RIMS1,CYP2AA1,ARL3,KALRN,ACSM2
    dioxygenase activity BCO1,KDM4C,BCO2L,KDM3A,HPDA,KDM6A,ADOA,PLOD1A,ASPHD2,PHF2

    Interacting Protein

    KDM4D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM4D here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM4D.

    PPP1CC;p27958-pro_0000037566

    Resources

    References

    • Shan, Z; Wan, J; et al. Study of lysine (K)-specific demethylase 4D (KDM4D) and senescence of mesenchymal stem cells. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE 8:291-292(2014).

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