KDM1B
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Official Full Name
lysine (K)-specific demethylase 1B
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Overview
Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009] -
Synonyms
KDM1B; lysine (K)-specific demethylase 1B; AOF1; LSD2; C6orf193; bA204B7.3; dJ298J15.2; lysine-specific histone demethylase 1B; amine oxidase, flavin containing 1; lysine-specific histone demethylase 2; amine oxidase (flavin containing) domain 1; flavin-containing amine oxidase domain-containing protein 1;
- Recombinant Proteins
- Antibody
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Rabbit
- Wheat Germ
- GST
- His
- Fc
- Avi
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | AOF1-642H | Recombinant Human AOF1 protein, GST-tagged | Wheat Germ | GST |
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| Human | KDM1B-1427HF | Recombinant Full Length Human KDM1B Protein, GST-tagged | In Vitro Cell Free System | GST | 619 amino acids |
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| Mouse | KDM1B-8586M | Recombinant Mouse KDM1B Protein | Mammalian Cell | His |
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| Mouse | KDM1B-4776M | Recombinant Mouse KDM1B Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Mouse | CPBT-38112RM | Rabbit Anti-Mouse KDM1B Polyclonal Antibody | Rabbit | Non |
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| Mouse | KDM1B-4776M-B | Recombinant Mouse KDM1B Protein Pre-coupled Magnetic Beads | HEK293 |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
KDM1B involved in several pathways and played different roles in them. We selected most pathways KDM1B participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | ATXN7L3;WDR77;ENY2;PRMT5;MSL2B;SMARCC1;ATF7IP;PADI3;RUVBL2 |
| Chromatin organization | CCDC101;JHDM1D;KANSL3;SMYD2A;EHMT2;PHF8;ASH2L;MCRS1;USP22 |
| HDMs demethylate histones | KDM2A;PHF8;KDM4D;KDM5BB;KDM6AL;KDM5A;KDM2AA;ARID5B;KDM6B |
KDM1B has several biochemical functions, for example, DNA binding, N-ethylmaleimide reductase activity, NADPH:sulfur oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM1B itself. We selected most functions KDM1B had, and list some proteins which have the same functions with KDM1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | RORCB;NR5A1A;ORC6L;ALX3;BHLHE22;PHC3;HOXC12A;GZF1;FOXD1 |
| N-ethylmaleimide reductase activity | HEPHL1;MOSC2;FRRS1;CYBASC3;KDM1B;CYB561A3A |
| NADPH:sulfur oxidoreductase activity | HEPHL1;FRRS1;CYBASC3;MICAL2;MICAL2B;KDM1B;CYB561A3A;MOSC2 |
| epoxyqueuosine reductase activity | CYB561A3A;MOSC2;CYBASC3;HEPHL1;KDM1B;FRRS1 |
| flavin adenine dinucleotide binding | TXNRD3;DMGDH;POR;SDHA;DLD;AIFM3;XDH;ETFDH;IVD |
| histone demethylase activity (H3-dimethyl-K4 specific) | KDM1A;KDM5BB;KDM1B;KDM5B |
| histone demethylase activity (H3-monomethyl-K4 specific) | |
| NOT histone demethylase activity (H3-trimethyl-K4 specific) | |
| malolactic enzyme activity | FRRS1;KDM1B;CYB561A3A;CYBASC3;MOSC2;HEPHL1 |
| metal ion binding | POMT1;CYP2AA7;ZNF32;DNTT;ALOX12E;GTF2E1;ILKAP;HBB-BH1;PLEKHM1P |
| oxidoreductase activity | HSD11B1L;PHF2;DHRS1;HSD11B1LA;CYP2AA7;CYP4T8;GPX1A;LEPREL1;EGLN1B |
| reduced coenzyme F420 dehydrogenase activity | HEPHL1;FRRS1;MOSC2;CYB561A3A;KDM1B;CYBASC3 |
| sulfur oxygenase reductase activity | CYB561A3A;MOSC2;CYBASC3;KDM1B;FRRS1;HEPHL1 |
| zinc ion binding | MARCH8;MIB2;TRAF5;MEP1B;CNOT4;PHF19;MAN2A2;CBLB;CBLC |
KDM1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM1B here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM1B.
Research Area
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