KDELR3
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Official Full Name
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 -
Overview
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment.Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae.This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER.In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein.Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described.KDELR3 was the third member of the family to be identified, and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins.Two transcript variants of KDELR3 that arise by alternative splicing, and encode different isoforms of KDELR3 receptor, have been described. -
Synonyms
KDELR3;KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3;ER lumen protein retaining receptor 3;KDEL receptor 3;KDEL endoplasmic reticulum protein retention receptor 3;ERD2L3
Recombinant Proteins
- Zebrafish
- Chicken
- Mouse
- Human
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Mus musculus
- zebrafish
- Xenopus laevis
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
KDELR3 involved in several pathways and played different roles in them. We selected most pathways KDELR3 participated on our site, such as IRE1alpha activates chaperones,Metabolism of proteins,Unfolded Protein Response (UPR), which may be useful for your reference. Also, other proteins which involved in the same pathway with KDELR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of proteins | PREB,RING1,DPH2,TOMM6,ADAMTS3,CPB1,FBXW5,NSMCE1,RAB27A,EXOC1 |
| Unfolded Protein Response (UPR) | PDIA6,CTDSP2,WIPI1,HDGF,YY2,KLHDC3,FKBP14,HYOU1,SERP1,DDX11 |
| XBP1(S) activates chaperone genes | HYOU1,SERP1,WIPI1,DDX11,FKBP14,CXXC1,C19orf10,ASNA1,YIF1A,SEC63 |
| IRE1alpha activates chaperones | SERP1,WIPI1,HDGF,C19orf10,HYOU1,ASNA1,SEC63,PREB,FKBP14,DNAJB9 |
| Vibrio cholerae infection | PRKACB,ATP6V1F,ATP6V0E1,ATP6V1C2,ATP6V1E1,ATP6V1B1,PDIA4,TJP1,ATP6V0B,ATP6V0A1 |
Protein Function
KDELR3 has several biochemical functions, for example, ER retention sequence binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KDELR3 itself. We selected most functions KDELR3 had, and list some proteins which have the same functions with KDELR3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ER retention sequence binding | KIAA1199,KDELR2A,KCNIP2,KDELR2B |
Interacting Protein
KDELR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDELR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KDELR3.
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References
- VILLEVAL, JL; MITJAVILA, MT; et al. AUTOCRINE STIMULATION BY ERYTHROPOIETIN (EPO) REQUIRES EPO SECRETION. BLOOD 84:2649-2662(1994).
- Lee, JH; Park, DY; et al. Intracellular Reprogramming of Expression, Glycosylation, and Function of a Plant-Derived Antiviral Therapeutic Monoclonal Antibody. PLOS ONE 8:-(2013).
