KCNQ2
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Official Full Name
potassium voltage-gated channel, KQT-like subfamily, member 2 -
Overview
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
KCNQ2;potassium voltage-gated channel, KQT-like subfamily, member 2;EBN;BFNC;EBN1;ENB1;BFNS1;EIEE7;HNSPC;KV7.2;KCNA11;KVEBN1;potassium voltage-gated channel subfamily KQT member 2;KQT-like 2;voltage-gated potassium channel subunit Kv7.2;neuroblastoma-specific potassium channel protein;neuroblastoma-specific potassium channel subunit alpha KvLQT2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KCNQ2-3222R | Recombinant Rat KCNQ2 Protein | Mammalian Cells | Rat | His |
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| KCNQ2-5019HCL | Recombinant Human KCNQ2 293 Cell Lysate | HEK293 | Human | Non |
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| KCNQ2-2878R | Recombinant Rat KCNQ2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| KCNQ2-2878R-B | Recombinant Rat KCNQ2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| KCNQ2-301222H | Recombinant Human KCNQ2 protein, GST-tagged | E.coli | Human | GST | Met1-Leu81 |
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Involved Pathway
KCNQ2 involved in several pathways and played different roles in them. We selected most pathways KCNQ2 participated on our site, such as Axon guidance,Cholinergic synapse,Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNQ2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Voltage gated Potassium channels | KCNG4A,KCNAB2,KCNV1,KCNH8,KCNC1B,KCNA6A,KCNV2,KCNAB1,KCNQ2A,KCNAB3 |
| L1CAM interactions | SCN4A,KIF4A,EZRA,DCX,SCN9A,CHL1,SCN3A,CNTN1,SCN3B,NADL1.1 |
| Interaction between L1 and Ankyrins | SCN8A,SCN2B,SCN3A,SCN4A,NADL1.1,SCN2A,KCNQ3,ANK2B,SCN9A,SCN3B |
| Axon guidance | MYL9,ARHGEF28,ARHGEF12,CLTB,DNM1,ACTR2,DOCK1,PPP3CB,DPYSL4,PSPN |
| Developmental Biology | MED15,EFNA5,NKX2.2A,SCN2A,MED26,GPC1A,MED10,LGI1,CACNG2B,SPRED1 |
| Neuronal System | DLG1L,ARL6IP5A,CHRNA3,HAND2,SLC17A7A,DLG3,SLC1A2B,Apba1,KCNMB2,SLC18A3A |
| Cholinergic synapse | CHRNB4,CAMK2G,PIK3R2,PIK3R3,PRKCG,AKT1,CREB3L1,GNG13,PIK3CD,GNB1 |
| Potassium Channels | KCNJ1B,KCNAB1,KCNJ1A.5,ABCC9,KCNB2,KCNC2,KCNB1,KCNH2,KCNK13A,KCNH6A |
Protein Function
KCNQ2 has several biochemical functions, for example, ankyrin binding,delayed rectifier potassium channel activity,potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNQ2 itself. We selected most functions KCNQ2 had, and list some proteins which have the same functions with KCNQ2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein N-terminus binding | ALOX5AP,TDRD7,PEX5,RASSF1,APTX,THAP7,ACTN4,TGFB1,HESX1,RPS21 |
| ankyrin binding | CDH1,KCTD6,SCN5A,KCNJ11,FLNC,OBSCN,SLC4A1,PTBP3,RHAG,PLEC |
| potassium channel activity | KCNK5A,KCNH6A,KCNQ2A,KCNK1B,KCNIP4,KCNK10,KCNA2,KCNF1,KCNK4,KCNK5 |
| delayed rectifier potassium channel activity | KCNC1B,KCNV2,KCNC1A,KCNC3A,KCNG1,KCNQ2A,KCNC1,KCNQ1,KCNQ3,KCNF1A |
| voltage-gated potassium channel activity | KCNAB3,HCN2,KCNA6A,KCNC1,KCNA6,KCNH5A,KCNC4,HCN4,KCNH6,KCNK5 |
Interacting Protein
KCNQ2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNQ2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNQ2.
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References
- Bocksteins, E; Van de Vijver, G; et al. K(v)3 channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 303:C406-C415(2012).
- Pulkes, T; Dejthevaporn, C; et al. Paroxysmal neuromyotonia: A new sporadic channelopathy. NEUROMUSCULAR DISORDERS 22:479-482(2012).
