KCNMB4
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Official Full Name
potassium large conductance calcium-activated channel, subfamily M, beta member 4 -
Overview
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. -
Synonyms
KCNMB4;potassium large conductance calcium-activated channel, subfamily M, beta member 4;calcium-activated potassium channel subunit beta-4;subfamily M subunit beta-4;BK channel subunit beta 4;BK channel subunit beta-4;BKbeta4;Calcium activated potassium channel beta 4 subunit;Calcium activated potassium channel subfamily M subunit beta 4;Calcium activated potassium channel subunit beta 4;Calcium-activated potassium channel;Charybdotoxin receptor subunit beta 4;Charybdotoxin receptor subunit beta-4;Hbeta4;K(VCA)beta 4;K(VCA)beta-4;KCMB4_HUMAN;KCNMB 4;Large conductance calcium dependent potassium ion channel beta 4 subunit;Maxi K channel subunit beta 4;Maxi K channel subunit beta-4;Potassium large conductance calcium activated channel subfamily M beta member 4;Slo beta 4;Slo-beta-4;OTTHUMP00000236251;calcium-activated potassium channel, subfamily M sub
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KCNMB4-274H | Recombinant Human KCNMB4, GST-tagged | E.coli | Human | GST | 46-176aa | |
| KCNMB4-4432C | Recombinant Chicken KCNMB4 | Mammalian Cell | Chicken | His |
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| KCNMB4-8541M | Recombinant Mouse KCNMB4 Protein | Mammalian Cell | Mouse | His |
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| KCNMB4-5022HCL | Recombinant Human KCNMB4 293 Cell Lysate | HEK293 | Human | Non |
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| KCNMB4-4751M | Recombinant Mouse KCNMB4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| KCNMB4-4751M-B | Recombinant Mouse KCNMB4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
KCNMB4 involved in several pathways and played different roles in them. We selected most pathways KCNMB4 participated on our site, such as cGMP-PKG signaling pathway,Vascular smooth muscle contraction,Insulin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNMB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vascular smooth muscle contraction | GNAQ,GNA12,ARHGEF1,GNA11A,PLA2G1B,GNAS,PRKACB,MYH11,PRKACA,ROCK2 |
| cGMP-PKG signaling pathway | SRF,ATP1A3,ROCK2,CALML5,PIK3R1,RHOA,TRPC6,PIK3R3,SLC8A1,OPRD1 |
| Insulin secretion | KCNMB1,ADCYAP1,INS,KCNMB2,ATP1B4,FXYD2,CREB3L3,VAMP2,ATF4,KCNN2 |
Protein Function
KCNMB4 has several biochemical functions, for example, calcium-activated potassium channel activity,potassium channel regulator activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNMB4 itself. We selected most functions KCNMB4 had, and list some proteins which have the same functions with KCNMB4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| potassium channel regulator activity | KCNIP1,DLG1,SUMO1,SGK2,AMIGO1,DPP10,ADRB2,NEDD4L,ABCC9,KCNV1 |
| calcium-activated potassium channel activity | PKD2L1,KCNMB2,KCNT1,KCNN1B,KCNN2,CCT8L2,KCNN1,KCNMB1,KCNMB3,KCNMA1 |
| protein binding | IL5RA,C9orf43,ARIH1,GPRASP1,MYL6,SIRT6,LACTB2,ANAPC4,LLGL2,CLNS1A |
Interacting Protein
KCNMB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNMB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNMB4.
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