KCNMB2
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Official Full Name
potassium large conductance calcium-activated channel, subfamily M, beta member 2 -
Overview
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Two variants encoding the same protein have been found for this gene. -
Synonyms
KCNMB2;potassium large conductance calcium-activated channel, subfamily M, beta member 2;calcium-activated potassium channel subunit beta-2;hbeta2;hbeta3;BKbeta2;hCG1646471;slo-beta-2;k(VCA)beta-2;BK channel subunit beta-2;MaxiK channel beta 2 s
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- GST
- His&Fc&Avi
Involved Pathway
KCNMB2 involved in several pathways and played different roles in them. We selected most pathways KCNMB2 participated on our site, such as Ca2+ activated K+ channels,Hemostasis,Insulin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNMB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Platelet homeostasis | SLC8A2A,KCNMB1,PDE10A,ATP2B1B,KCNMA1,ATP2B3A,APOER2 |
| Insulin secretion | KCNMB3,ATP1A3,PRKCA,PLCB2,PRKACA,RIMS2,SNAP25,GCG,ATP1B4,ATF4 |
| Neuronal System | KCNQ2,KCNB2,CHRND,MYO6,KCNA6A,KCNH1B,KCNN1B,KCNK4,RAB3AA,KCND3 |
| Potassium Channels | KCNK7,KCNJ1A.5,KCNA1,KCNJ1B,KCNA6,KCNH2A,KCNN1,KCNAB2,KCNN1B,KCNK4 |
| Ca2+ activated K+ channels | KCNN3,KCNN1,KCNN1B,KCNN2,KCNMB1,KCNN4,KCNN1A,KCNMA1 |
| Hemostasis | DOK2,CD9A,AKAP1B,SLC7A11,ANXA2B,TAE1,GNA13,PROCR,KIF15,SCG3 |
| Vascular smooth muscle contraction | PPP1CAB,BRAF,ARAF,CALM2B,PRKG1A,CALM4,PRKACB,ITPR1,CALM1B,PTGIR |
| Nitric oxide stimulates guanylate cyclase | PDE10A,KCNMA1,KCNMB1 |
Protein Function
KCNMB2 has several biochemical functions, for example, calcium-activated potassium channel activity,ion channel inhibitor activity,potassium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNMB2 itself. We selected most functions KCNMB2 had, and list some proteins which have the same functions with KCNMB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium-activated potassium channel activity | CCT8L2,KCNMA1A,HPN,KCNN1,PKD2L1,KCNT1,MTMR6,KCNN1A,KCNMB4,KCNN4 |
| ion channel inhibitor activity | KCNV1,STOML1,ENSA,PDZD3,GNB2L1,RSC1A1 |
| potassium channel regulator activity | PIAS3,DRD4,SUMO1,ADRB2,KCNAB1,KCNE1L,NEDD4L,SGK2B,PRKCZ,KCNS3 |
Interacting Protein
KCNMB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNMB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNMB2.
KCNMA1
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References
- Beecham, GW; Hamilton, K; et al. Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias. PLOS GENETICS 10:-(2014).
- Wong, AHC; Lipska, BK; et al. Cortical gene expression in the neonatal ventral-hippocampal lesion rat model. SCHIZOPHRENIA RESEARCH 77:261-270(2005).
