KCNK10
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Official Full Name
potassium channel, subfamily K, member 10 -
Overview
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. -
Synonyms
KCNK10;potassium channel, subfamily K, member 10;potassium channel subfamily K member 10;K2p10.1;TREK 2;TREK2;Outward rectifying potassium channel protein TREK 2;Potassium channel TREK 2;TREK 2 K;TWIK related K+ channel 2;OTTHUMP00000244287;OTTHUMP00000244288;OTTHUMP00000244289;potassium channel TREK-2;TWIK-related K+ channel 2;TREK-2 K(+) channel subunit;2P domain potassium channel TREK2;outward rectifying potassium channel protein;TREK-2
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
KCNK10 involved in several pathways and played different roles in them. We selected most pathways KCNK10 participated on our site, such as Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNK10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gastric acid secretion | Slc4a2,MYLK,SLC9A1,PLCB4,KCNE2,CA2,CALML3,CALM4,ATP1A4,KCNJ15 |
Protein Function
KCNK10 has several biochemical functions, for example, potassium channel activity,potassium ion leak channel activity,voltage-gated ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNK10 itself. We selected most functions KCNK10 had, and list some proteins which have the same functions with KCNK10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| potassium ion leak channel activity | KCNK5,KCNK6,KCNK5B,KCNK13A,KCNK9,KCNK3,TMEM175,KCNK1B,KCNK13B,KCNK10B |
| potassium channel activity | KCNK10B,KCNK5A,DDX1,KCNS3B,KCNJ11L,KCNC4,KCNV2B,KCNK1B,KCNK5B,TMEM38B |
| voltage-gated ion channel activity | CYBB,KCNV2,KCNK7,SCN8AA,KCNC2,KCNF1A,KCNS3A,CACNA1SA,KCNA2B,KCNB2 |
Interacting Protein
KCNK10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNK10 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNK10.
PPP1CA;Akap5
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