KCNJ8
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Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 8 -
Overview
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. -
Synonyms
KCNJ8;potassium inwardly-rectifying channel, subfamily J, member 8;ATP-sensitive inward rectifier potassium channel 8;Kir6.1;inward rectifier K(+) channel Kir6.1;inwardly rectifying potassium channel KIR6.1;potassium channel, inwardly rectifying sub
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Mouse
- Chicken
- Mus musculus
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- HEK293
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
KCNJ8 involved in several pathways and played different roles in them. We selected most pathways KCNJ8 participated on our site, such as ATP sensitive Potassium channels,Inwardly rectifying K+ channels,Neuronal System, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNJ8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inwardly rectifying K+ channels | KCNJ10,KCNJ1B,KCNJ1A.5,KCNJ11,KCNJ1A.6,KCNJ1A.2,KCNJ1A.3,KCNJ14,GNGT2B,KCNJ1 |
| ATP sensitive Potassium channels | KCNJ11,ABCC9 |
| Potassium Channels | KCNK7,KCNB1,KCNN4,KCNA4,KCNJ1A.5,KCNH6,KCNK13B,KCNH5A,KCNJ1A.1,KCNS3A |
| SIDS Susceptibility Pathways | ECE1,RUNX3,DLX2,POU2F2,FOXM1,PLP1,KCNQ1,CREM,TPPP,DEAF1 |
| cGMP-PKG signaling pathway | PLCB2,FXYD2,CALML3,ATP2A1,PIK3CG,ROCK1,PPP3R1,PPP1CB,MEF2B,BNP |
| Neuronal System | HCN4,GLS2B,HAND2,CHRNA4,CACNB4B,SLC17A7A,SLC6A1A,KCNC1,CHRNE,KCNK13A |
Protein Function
KCNJ8 has several biochemical functions, for example, ATP binding,ATP-activated inward rectifier potassium channel activity,NOT G-protein activated inward rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNJ8 itself. We selected most functions KCNJ8 had, and list some proteins which have the same functions with KCNJ8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP-activated inward rectifier potassium channel activity | KCNJ1,KCNJ1A.5,KCNJ11L,KCNJ1A.6,KCNJ11,KCNJ1B,KCNJ10,KCNJ1A.2,KCNJ1A.3,KCNJ1A.1 |
| sulfonylurea receptor binding | HSP90AB1 |
| ATP binding | ERCC3,ERN2,GKUP,CAMK2G,TTLL3,EIF4A3,CSNK1G2,PDPK1B,NLRP9B,OPLAH |
| inward rectifier potassium channel activity | KCNK6,KCNJ2,KCNJ1A.2,KCNJ14,KCNJ2A,KCNJ1A.3,KCNJ18,KCNJ15,KCNJ1A.5,KCNQ5 |
| NOT G-protein activated inward rectifier potassium channel activity | KCNJ11L,KCNJ11 |
Interacting Protein
KCNJ8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNJ8 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNJ8.
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References
- Li, Q; Chen, M; et al. KCNJ11 E23K variant is associated with the therapeutic effect of sulphonylureas in Chinese type 2 diabetic patients. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 41:748-754(2014).
- Qin, LJ; Lv, Y; et al. Meta-analysis of association of common variants in the KCNJ11-ABCC8 region with type 2 diabetes. GENETICS AND MOLECULAR RESEARCH 12:2990-3002(2013).
