KCNJ15
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Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 15 -
Overview
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Three transcript variants encoding the same protein have been found for this gene. -
Synonyms
KCNJ15;potassium inwardly-rectifying channel, subfamily J, member 15;ATP-sensitive inward rectifier potassium channel 15;IRKK;Kir1.3;Kir4.2;inwardly rectifying subfamily J member 15;ATP sensitive inward rectifier potassium channel 15;Inward rectifier K(+) channel Kir1.3;Inward rectifier K(+) channel Kir4.2;Inward rectifier K+ channel KIR4.2;IRK15_HUMAN;KCNJ 14;KCNJ 15;KCNJ14;MGC13584;Potassium channel;Potassium channel inwardly rectifying subfamily J member 15;Potassium inwardly rectifying channel J15;Potassium inwardly rectifying channel subfamily J member 15;OTTHUMP00000115737;OTTHUMP00000115738;OTTHUMP00000115740;OTTHUMP00000115742;OTTHUMP00000115743;OTTHUMP00000115746;inward rectifier
Recombinant Proteins
- Human
- Rat
- Mouse
- Mus musculus
- Guinea pig
- Wheat Germ
- Mammalian Cells
- E.Coli/Yeast
- HEK293
- E.coli
- Non
- His
- His&Fc&Avi
Involved Pathway
KCNJ15 involved in several pathways and played different roles in them. We selected most pathways KCNJ15 participated on our site, such as Activation of G protein gated Potassium channels,Activation of GABAB receptors,G protein gated Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNJ15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | KCNJ12,GNGT2B,KCNJ2A,KCNJ10,KCNJ4,GNGT2A |
| GABA B receptor activation | KCNJ12,GNGT2B,KCNJ9,KCNJ4,KCNJ5,GNGT2A,GNB3A,KCNJ2,KCNJ2A,KCNJ6 |
| GABA receptor activation | KCNJ2A,KCNJ12,GNB3A,KCNJ2,GNGT2A,ARHGEF9,GABRR2A,GNGT2B,KCNJ9,KCNJ10 |
| Activation of GABAB receptors | GNGT2A,GNB3B,KCNJ4,KCNJ6,KCNJ2A,KCNJ10,ADCY7,ADCY1,GNB3A,KCNJ5 |
| Activation of G protein gated Potassium channels | KCNJ6,KCNJ3,KCNJ2A,GNGT2B,KCNJ9,KCNJ12,KCNJ4,GNB3B,GNB3A,KCNJ5 |
| G protein gated Potassium channels | KCNJ5,KCNJ6,KCNJ12,GNGT2B,GNB3B,GNB3A,KCNJ10,KCNJ2A,GNGT2A,KCNJ9 |
| Inwardly rectifying K+ channels | KCNJ1A.4,KCNJ1A.3,KCNJ1A.5,GNGT2B,ABCC9,KCNJ1B,KCNJ10,KCNJ1A.2,KCNJ1,KCNJ11 |
| Gastric acid secretion | SLC26A7,ACTB,ATP1B4,CALM1,SSTR2,CALML5,ITPR3,ATP1A2,PLCB1,KCNK2 |
Protein Function
KCNJ15 has several biochemical functions, for example, inward rectifier potassium channel activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNJ15 itself. We selected most functions KCNJ15 had, and list some proteins which have the same functions with KCNJ15. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inward rectifier potassium channel activity | KCNJ2,KCNJ13,KCNK1,KCNJ1A.3,KCNJ18,KCNJ1A.4,KCNJ16,KCNJ1A.2,KCNJ1A.6,KCNJ11L |
| protein binding | METTL17,ADAMTS5,PROP1,SIN3B,ACKR4,MOBKL2B,KCNB1,CTAG2,ZNF34,DOK1 |
Interacting Protein
KCNJ15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNJ15 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNJ15.
Il16;Inadl
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References
- Qin, LJ; Lv, Y; et al. Meta-analysis of association of common variants in the KCNJ11-ABCC8 region with type 2 diabetes. GENETICS AND MOLECULAR RESEARCH 12:2990-3002(2013).
- Okamoto, K; Iwasaki, N; et al. Inhibition of Glucose-Stimulated Insulin Secretion by KCNJ15, a Newly Identified Susceptibility Gene for Type 2 Diabetes. DIABETES 61:1734-1741(2012).
