KCNG4

  • Official Full Name

    potassium voltage-gated channel, subfamily G, member 4

  • Overview

    Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues.

  • Synonyms

    KCNG4;potassium voltage-gated channel, subfamily G, member 4;potassium voltage-gated channel subfamily G member 4;Kv6.4;voltage-gated potassium channel Kv6.3;voltage-gated potassium channel subunit Kv6.4;KV6.3;MGC4558;MGC129609

    Involved Pathway

    KCNG4 involved in several pathways and played different roles in them. We selected most pathways KCNG4 participated on our site, such as Metabolic pathways,Metabolism,Metabolism of vitamins and cofactors, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNG4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolic pathways CTPS2,PTGS1,CYP2A4,BCO1,PMM1,IDO2,EXTL2,ATP6V1C1A,CBSA,LDHB
    Nicotinate and nicotinamide metabolism NT5C3L,CD38,NT5C2B,NADKB,NMNAT1,NT5C1B,PNP6,NMNAT3,NT5C1BA,PNP
    Metabolism of vitamins and cofactors SLC46A1,TCN1,MOCOS,MMADHC,SLC25A16,SLC25A32,SLC23A2,GPHNA,GPHN,SLC5A6B
    Metabolism FABP1B.1,SLC4A1B,VAPB,SGMS2,MMS19,OAZ3,COX11,NDUFAF6,SLC16A8,DIO2
    Metabolism of water-soluble vitamins and cofactors SLC23A2,SLC5A6B,SLC2A3,NAMPT,SLC52A3,GSTO2,CBLC-1,SLC46A1,CYB5A,SLC19A2

    Protein Function

    KCNG4 has several biochemical functions, for example, ligase activity,nicotinate phosphoribosyltransferase activity,nicotinate-nucleotide diphosphorylase (carboxylating) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNG4 itself. We selected most functions KCNG4 had, and list some proteins which have the same functions with KCNG4. You can find most of the proteins on our site.

    Function Related Protein
    nicotinate-nucleotide diphosphorylase (carboxylating) activity NAPRT,NAPRT1,NAMPT,NAMPTB,QPRT
    ligase activity RAD18,TRIM21,PPIL2,MGRN1A,TRAF2,ARIH1,MARCH3,TRIM58,RNF130,NAPRT1
    protein binding CST3,UBE3C,SEPT10,CXCR2,RSRC2,RAB6A,TGFB1I1,ZNF317,NPHP3,ZBTB8A
    nicotinate phosphoribosyltransferase activity NAPRT1,NAPRT

    Interacting Protein

    KCNG4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNG4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNG4.

    Resources

    References

    • Been, LF; Ralhan, S; et al. Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: A study of 3,310 subjects from India and the US. BMC MEDICAL GENETICS 12:-(2011).
    • Miceli, F; Cilio, MR; et al. Gating currents from neuronal K(V)7.4 channels General features and correlation with the ionic conductance. CHANNELS 3:274-283(2009).
    • Christie, MJ; et al. Molecular and functional diversity of K+ channels. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 22:944-951(1995).

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